Cytochalasin B

SKU
C-1027
  • CAS:14930-96-2
  • Formula:C29H37NO5
  • MW:479.6 Da
  • Appearance:white powder
  • Purity:>99% (TLC)

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Starting at $139.99

Product Name Qty
Cytochalasin B, Helminthosporium dematioideum
5 mg
$139.99
Cytochalasin B, Helminthosporium dematioideum
25 mg
$629.99
Cytochalasin B, Helminthosporium dematioideum
10 mg
$249.99

Description

Cytochalasin B is a heterotricyclic compound that acts as a mycotoxin. Cytochalasin B inhibits cytokinesis during cell division by preventing microfilament formation. While preventing cytokinesis from occurring, this compound exerts no effect on the division of the nucleus. Cytochalasin B also inhibits several processes within cells, including both the formation of actin filaments and the normal transport of glucose. Cytochalasin B acts as a microtubule inhibitor isolated from Helminthosporium dematioideum.

Applications

Owing to its ability to permeate cells and inhibit several aspects of their ordinary activity, cytochalasin B has been used widely in cytological research to investigate cellular processes. Along with the other cytochalasins, this compound has also been studied as a potential anticancer drug. In both in vitro and in vivo studies, cytochalasins have been shown to damage cancerous cells to a greater extent than non-cancerous cells. Another line of investigation into cytochalasin B's in vivo effects has focused on its ability to restore elasticity to the skin cells of mice by impeding f-actin polymerization. Cytochalasin B also induces cellular DNA Fragmentation.

More Information
Alternate Name/Synonyms
Phomin; NSC 107658
SKU
C-1027
CAS #
14930-96-2
Chemical Name
(1S,4E,6R,10R,12E,14S,15S,17S,18S,19S)-19-benzyl-6,15-dihydroxy-10,17-dimethyl-16-methylidene-2-oxa-20-azatricyclo[12.7.0.01,18]henicosa-4,12-diene-3,21-dione
Chemical Formula
C29H37NO5
Molecular Weight
479.6 Da
Appearance
white powder
Purity
>99% (TLC)
Solubility
Soluble in Methanol, DMSO and DMF
Melting Point
225‚°C
Preparation
N/A
Storage Temp
+4°C, desiccated
THERAPEUTIC AREA
Not Applicable
USE
For laboratory and research purpose only. Cytochalasin B is often used in cytological research. It inhibits cytoplasmic division by blocking the formation of contractile microfilaments. It inhibits cell movement and induces nuclear extrusion. Cytochalasin B shortens actin filaments by blocking monomer addition at the fast-growing end of polymers. Cytochalasin B inhibits glucose transport and platelet aggregation. It blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells.
Merck Index
13.2819.2001
RTECS
N/A
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
Citations
DEVELOPMENTAL BIOLOGY: Polychaete trunk neuroectoderm converges and extends by mediolateral cell intercalation Patrick R. H. Steinmetz, Fabiola Zelada-Gonzáles, Carola Burgtorf, Joachim Wittbrodt, and Detlev Arendt PNAS, Feb 2007; 104: 2727 - 2732.
Citations_Hyperlink
http://www.pnas.org/cgi/reprint/104/8/2727
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
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