Daminozide, KDM2/7 demethylase inhibitor

SKU
D-2633
  • CAS:1596-84-5
  • Formula:C6H12N2O3
  • MW:160.17
  • Appearance:White solid
  • Purity:98% by TLC NMR (Conforms)
Product Name Qty
Daminozide, KDM2/7 demethylase inhibitor
5 mg
$96.07

Daminozide (1596-84-5) is a selective inhibitor of the KDM2/7 JmjC subfamily of histone demethylases. IC50=1.5, 0.55 and 2.1 μM for KDM2A, PHF8 and KDM7A respectively. Highly selective over other subfamily members (KDM3, KDM4, KDM5 and KDM6) as well as other 2-oxoglutarate oxygenases (FIH, PHD2 and BBOX1), IC50> 100 μM.

More Information
Alternate Name/Synonyms
N-(Dimethylamino)succinamic acid
SKU
D-2633
CAS #
1596-84-5
Chemical Name
1-(2,2-Dimethylhydrazide)butanedioic acid
Chemical Formula
C6H12N2O3
Molecular Weight
160.17
Appearance
White solid
Purity
98% by TLC NMR (Conforms)
Solubility
Soluble in DMSO (up to 50 mg/ml), or in Water (up to 20 mg/ml with warming).
Stability
Stable for 3 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Storage Temp
RT (des.)
Hazard Image
Yes
Promo text for AGS discount
N/A
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