DAPT

SKU
D-1210
  • CAS:208255-80-5
  • Formula:C23H26F2N2O4
  • MW:432.5 Da
  • Appearance:White to off-white solid
  • Purity:>98%

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Product Name Qty
DAPT
5 mg
$60.00
DAPT
25 mg
$185.00

Description

DAPT is a cell permeable inhibitor of γ-secretase (IC=115 nM for totalamyloid, IC=200 nM foramyloid 1-42). It does not inhibit presenilinase. DAPT antagonizes Notch signaling through inhibition of Notch processing. DAPT treatment can influence hematopoietic cell fate decisions and enhances neuronal differentiation in embryonic stel cell-derived embryoid bodies independent of sonic hedgehog (Shh) signaling.

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
GSI-IX; gamma-Secretase Inhibitor IX; N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine tert-butyl ester
SKU
D-1210
CAS #
208255-80-5
Chemical Name
tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate
Chemical Formula
C23H26F2N2O4
Molecular Weight
432.5 Da
Appearance
White to off-white solid
Purity
>98%
Solubility
Soluble in 100% Ethanol, DMSO, or Dichloromethane
Preparation
Aliquots should be stored at -20°C, Stock solutions stable up to 3 months.
Storage Temp
-20°C
THERAPEUTIC AREA
Neurological Disorders
USE
A potent and specific inhibitor of gamma-secretase use in Alzheimer's disease.
MDL NUMBER
MFCD04974585
CHEMACX
X1460779-7
INCHI
InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1
SMILES
C[C@@H](C(=O)N[C@@H](c1ccccc1)C(=O)OC(C)(C)C)NC(=O)Cc2cc(cc(c2)F)F
Handling
Packaged under inert gas. Protect from light.
Certificate of Analysis 1
Certificate of Analysis 2
Handling Packaged under inert gas. Protect from light.
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