Dasatinib

SKU
C-2281
  • CAS:302962-49-8
  • Formula:C22H26ClN7O2S
  • MW:488.01
  • Appearance:White to off-white Solid
  • Purity:99% by HPLC

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Product Name Qty
Dasatinib
100 mg
$256.29
Dasatinib
25 mg
$119.60

Dasatinib is a multi-kinase inhibitor with potent activity against BCRABL kinase (IC50 = 0.21.1 nM). Dasatinib also inhibits Lyn (IC= 8.5 nM) and Src (IC= 3.0 nM) kinase activities in vitro using 0.1 mg/mL poly (Glu4-Tyr) as the substrate. Dasatinib is used to treat certain adult patients with Philadelphia chromosome-positive chronic myeloid leukemia (CML) or acute lymphoblastic leukemia (ALL).

More Information
Alternate Name/Synonyms
BMS-354825, Sprycel
SKU
C-2281
CAS #
302962-49-8
Chemical Name
N-(2-CHLORO-6-METHYLPHENYL)-2-[[6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL]AMINO]-1,3-THIAZOLE-5-CARBOXAMIDE
Chemical Formula
C22H26ClN7O2S
Molecular Weight
488.01
Appearance
White to off-white Solid
Purity
99% by HPLC
Solubility
DMSO (200 mg/ml)
Melting Point
261-285 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Src and Bcr/Abl kinase inhibitor
MDL NUMBER
MFCD11046566
CHEMACX
X1578549-6
INCHI
InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
SMILES
Cc1cccc(c1NC(=O)c2cnc(s2)Nc3cc(nc(n3)C)N4CCN(CC4)CCO)Cl
Handling
Protect from light and moisture
GHS PICTOGRAMS
Handling Protect from light and moisture
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