DDTT

SKU
C-2000
  • CAS:1192027-04-5
  • Formula:C5H7N3S3
  • MW:205.31 Da

1

0

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Product Name Qty
DDTT
1 g
$90.00
DDTT
5 g
$450.00

Description

DDTT, popularly known as Beaucage Reagent, has found common use for the sulfurization of oligonucleotides because of its high efficiency, fast reaction time, and widespread availability.

Solubility of DDTT

Concentration of DDTT Pyridine:ACN Pyridine:THF
0.1M 100:0 40:60
0.06M 50:50 -
0.05M 40:60 20:80
0.03M 30:70 -
0.02M 20:80 0:100

 

 

More Information
Alternate Name/Synonyms
Sulfurizing Reagent II; 3-((N,N-dimethylaminomethylidene)amino)-3H-1,2,4-dithiazole-5-thione
SKU
C-2000
CAS #
1192027-04-5
Chemical Name
N,N-dimethyl-N'-(5-sulfanylidene-1,2,4-dithiazol-3-yl)methanimidamide
Chemical Formula
C5H7N3S3
Molecular Weight
205.31 Da
Solubility
The solubility of DDTT in mixtures of anhydrous pyridine and acetonitrile or anhydrous pyridine and THF is relatively limited and increases with the increasing concentration of pyridine.
Stability
At least 6 months
Melting Point
178-179°C
Storage Temp
Controlled room temperature or lower, dry.
USE
A new sulfurizing reagent exhibits all the good properties of Beaucage Reagent while adding good stability in solution on the synthesizer and offering strong ability to sulfurize RNA linkages. 0.05 M solution of Sulfurizing Reagent II is recommended for the synthesis of RNA phosphorothioates. A sulfurizing time of 2-4 minutes generated oligophosphorothioates of high quality. Sulfurizing Reagent II was compared to Beaucage Reagent in the synthesis of DNA phosphorothioates. The quality of the products was identical with both reagents. In DNA synthesis, the cycle efficiency seemed to be optimal for Sulfurizing Reagent II when using a 60 second sulfurizing time.
Handling
Avoid prolonged exposure. Use caution when handling. Exposure to any chemical should be limited. Do not breath dust or vapor. Have safety shower and eye wash available. Do not get in eyes, on skin or on clothing. Keep container tightly closed. Store in a cool, dry, well-ventilated place. Ensure adequate ventilation during use. Use only in a chemical fume hood
GHS PICTOGRAMS
Handling Avoid prolonged exposure. Use caution when handling. Exposure to any chemical should be limited. Do not breath dust or vapor. Have safety shower and eye wash available. Do not get in eyes, on skin or on clothing. Keep container tightly closed. Store in a cool, dry, well-ventilated place. Ensure adequate ventilation during use. Use only in a chemical fume hood
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