Dexamethasone

SKU
D-2287
  • CAS:50-02-2
  • Formula:C22H29FO5
  • MW:392.5
  • Appearance:Crystalline solid
  • Purity:≥98%

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Product Name Qty
Dexamethasone
1 g
$112.77
Dexamethasone
10 g
$563.84

Description

Dexamethasone is an anti-inflammatory glucocorticoid. Inhibits the expression of the inducible but not the constitutive nitric oxide synthase in vascular endothelial cells (IC= 5 nM). Enhances active cation transport in aortic smooth muscle cells by stimulating the Na+-K+ pump.

It has anti-inflammatory and anti-rheumatic properties. Induces apoptosis in human thymocytes. In general, 500-1000 nM of dexamethasone is sufficient to induce apoptosis following a 6-hour incubation at 37°C.

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
9-fluoro-11β,17,21-trihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione; Dexamethazone
SKU
D-2287
CAS #
50-02-2
Chemical Name
(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Chemical Formula
C22H29FO5
Molecular Weight
392.5
Appearance
Crystalline solid
Purity
≥98%
Solubility
DMSO ( 25 mg/mL) or EtOH
Storage Temp
-20°C
THERAPEUTIC AREA
Inflammatory Diseases
USE
Dexamethasone is used to treat many inflammatory and autoimmune conditions, such as rheumatoid arthritis and bronchospasm.
MDL NUMBER
MFCD00064136
CHEMACX
X1011594-5
INCHI
InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
SMILES
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C
RTECS
TU3980000
Handling
Protect from light and moisture
GHS PICTOGRAMS
Handling Protect from light and moisture
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