Dextran Sulfate Sodium Salt

SKU
D-2571
  • CAS:9011-18-1
  • Formula:C12H22O25S5
  • MW:726.583 Da
  • Appearance:White to off-white crystalline powder
  • Purity:≥ 98.0 %

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Product Name Qty
Dextran Sulfate Sodium Salt
50 g
$127.49
Dextran Sulfate Sodium Salt
100 g
$193.79

Description

Dextran sulfate is a polyanionic compound that is derived from the branched glucan dextran. It is made through the esterification of dextran and chlorosulphonic acid.

For solution format, see product Dextran Sulfate, 50% Solution (D-2603).

 

Applications

In laboratory settings, dextran sulfate is used widely for hybridization of nucleic acids. Specifically, dextran sulfate has the ability to accelerate the hybridization process by exerting an excluded volume effect on reaction mixes. This effect ultimately concentrates the relevant probe at mRNA strands. The compound is also used in studies of ulcerative colitis and other forms of inflammatory bowel disease (IBD), which it can induce chemically in mice. Dextran sulfate has also been explored as a drug for blocking the instant blood-mediated inflammatory reaction in islet transplantation recipients due to its ability to block the activation of serum coagulants and complement.

• Nucleic acid hybridizations: accelerant for faster probe annealing
• Anti-coagulant properties due to ability to precipitate lipoproteins from plasma solutions
• Ribosomal isolations

 

Specifications

• Free sulfate content: <0.02%
• RNase: not detected
• DNase: not detected

 

More Information
Alternate Name/Synonyms
Detralfate; Detralfato; Detralfatum
SKU
D-2571
CAS #
9011-18-1
Chemical Name
[(2S,3R,4S,5R,6R)-2-hydroxy-6-[[(2S,3R,4S,5R,6R)-5-hydroxy-6-methyl-3,4-disulfooxyoxan-2-yl]oxymethyl]-3,5-disulfooxyoxan-4-yl] hydrogen sulfate
Chemical Formula
C12H22O25S5
Molecular Weight
726.583 Da
Appearance
White to off-white crystalline powder
Purity
≥ 98.0 %
Solubility
Water 100 g/l at 25 °C (77 °F)
Storage Temp
Room temperature
THERAPEUTIC AREA
Not Applicable
USE
Dextran Sulfate is used as an adjuvant in blood transfusion, an anticoagulant. used as an anticoagulant and recently investigated for its antiviral activity.
Handling
Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
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