- MW:137.23 Da
Dithiobutylamine (DTBA) is a dithiol that can be synthesized from L-aspartic acid (A790021). Dithiobutylamine is a potent and versatile disulfide-reducing agent that is capable of reducing the enzyme papain, which has a relatively anionic active site, 14 times as fast as DTT could.
DTBA has thiol pKa values that are approximately 1 unit lower than DTT and forms a disulfide with a similar E value. Dithiobutylamine reduces disulfide bonds faster than DTT, especially in neutral aqueous systems. The amino group of DTBA enables its isolation by cation exchange and facilitates its conjucation.
Dithiobutylamine has very desirable physicochemical attributes. The HCl salt of DTBA is nearly odorless with a high solubility in water.
|Handling||Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.|