DMNQ

SKU
D-2597
  • CAS:6956-96-3
  • Formula:C12H10O4
  • MW:218.2 Da
  • Appearance:Yellow crystalline solid
  • Purity:≥99% (NMR)

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DMNQ
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A cell-permeable, non-alkylating, non-thiol, adduct-forming, redox cycling quinone. Can be used to eliminate any mechanistic ambiguity involving redox cycling quinoids as the source of reactive oxidant species/oxidative stress in biological studies. DMNQ is also reported to result in either cell proliferation or apoptotic or necrotic cell death, depending upon the concentration used.

More Information
Alternate Name/Synonyms
DiMeNQ; NSC 69355; 2,3-Dimethoxy-1,4-naphthoquinone; 2,3-Dimethoxynaphthoquinone
SKU
D-2597
CAS #
6956-96-3
Chemical Name
2,3-dimethoxynaphthalene-1,4-dione
Chemical Formula
C12H10O4
Molecular Weight
218.2 Da
Appearance
Yellow crystalline solid
Purity
≥99% (NMR)
Solubility
Soluble in DMSO or methanol
Storage Temp
-20°C (long term), +4°C (short term)
THERAPEUTIC AREA
Oncological disorders
USE
DMNQ induces cell proliferation, apoptosis, necrosis and necroptosis in vitro, dependent on concentration, time, temperature and cell type. It is valuable tool for the generation of reactive oxygen species (ROS) in order to study the role of ROS in cell toxicity, apoptosis and necrosis. It also useful as reference compound in characterizing the effects of oxidative stress.
Handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire protection.
GHS PICTOGRAMS
Handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire protection.
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