DMOG (Dimethyloxalylglycine)

SKU
D-2637
  • CAS:89464-63-1
  • Formula:C6H9NO5
  • MW:175.14 Da
  • Appearance:Off-white solid
  • Purity:99% by TLC, NMR (Conforms)

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Product Name Qty
DMOG (Dimethyloxalylglycine)
50 mg
$183.15

Description

Dimethyloxalylglycine (DMOG) inhibits PHD or prolyl hydroxylase domain-containing proteins, activating HIF1α and inhibiting JMJD2A (IC50 = 2.5 μM). Displays neuroprotective effects. Inhibits neuronal cell death caused by neurotrophin deprivation. DMOG prevents activation of the ATR/CHK1/p53 pathway and suppresses apoptosis induced by DNA damage.

Inhibits prolyl hydroxylase domain-containing proteins

More Information
Alternate Name/Synonyms
Dimethyloxalylglycine
SKU
D-2637
CAS #
89464-63-1
Chemical Name
methyl 2-[(2-methoxy-2-oxoethyl)amino]-2-oxoacetate
Chemical Formula
C6H9NO5
Molecular Weight
175.14 Da
Appearance
Off-white solid
Purity
99% by TLC, NMR (Conforms)
Solubility
Soluble in DMSO (up to 25 mg/mL) or in Ethanol (up to 25 mg/mL)
Stability
Stable for 2 years as supplied. Solutions are not stable. Solutions must be made fresh and used within 1 working day.
Storage Temp
-20°C, desiccated. Protect from light.
USE
Inhibits prolyl hydroxylase domain-containing proteins
Handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs
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GHS PICTOGRAMS
Handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols.Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs
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