DMPO

SKU
D-2449
  • CAS:3317-61-1
  • Formula:C6H11NO
  • MW:113.16 Da
  • Appearance:Clear to pale yellow low-melting solid
  • Purity:≥98%

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Product Name Qty
DMPO
1 g
$159.47

Description

5,5-Dimethyl-1-pyrroline N-oxide (DMPO) is commonly used as a cell-permeable, hydrophilic spin trap agent for studies of superoxide, S-, O-, C- and N- centered free radicals in electron paramagnetic resonance (EPR). This agent is water-soluble and able to penetrate lipid bilayers.

It has demonstrated neuroprotective properties. The presence of DMPO while incubation of lymphocytes decreases DNA damage by NiCl. It is reported that the recovery of heart function is improved in DMPO-treated hearts in a rat model.

 

Applications

• Study of free radicals

• Detection of superoxide

 

References

• “Heart protection and radical trapping by DMPO during reperfusion in isolated working rat hearts”

• “ESR measurement of rapid penetration of DMPO and DEPMPO spin traps through lipid bilayer membranes”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
5,5-Dimethyl-1-pyrroline N-oxide
SKU
D-2449
CAS #
3317-61-1
Chemical Name
2,2-dimethyl-1-oxido-3,4-dihydropyrrol-1-ium
Chemical Formula
C6H11NO
Molecular Weight
113.16 Da
Appearance
Clear to pale yellow low-melting solid
Purity
≥98%
Solubility
May be dissolved in DMSO (25 mg/ml); or ethanol (25mg/ml)
Melting Point
30 °C
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
Not Applicable
USE
DMPO is a commonly used as a cell permeable hydrophilic spin trap for studies of superoxide, S-, O-, C- and N- centered free radicals. It has demonstrated neuroprotective properties. When lymphocytes were incubated in the presence of DMPO, DMPO decreased NiCl induced DNA damage.
MDL NUMBER
MFCD00005279
CHEMACX
X1078779-4
INCHI
InChI=1S/C6H11NO/c1-6(2)4-3-5-7(6)8/h5H,3-4H2,1-2H3
SMILES
CC1(CCC=[N+]1[O-])C
Handling
Ensure adequate ventilation, especially in confined areas. Use personal protective equipment as required. Use with local exhaust ventilation. Do not breathe dust/fume/gas/mist/vapors/spray.
Certificate of Analysis 1
Certificate of Analysis 2
Handling Ensure adequate ventilation, especially in confined areas. Use personal protective equipment as required. Use with local exhaust ventilation. Do not breathe dust/fume/gas/mist/vapors/spray.
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