Doramapimod

SKU
D-2294
  • CAS:285983-48-4
  • Formula:C31H37N5O3
  • MW:527.66
  • Appearance:White to off-white Solid
  • Purity:98% by HPLC
Product Name Qty
Doramapimod
25 mg
$324.64
Doramapimod
5 mg
$85.43
Cell-permeable. A potent protein kinase inhibitor with a 330-fold selectivity for p38 MAPK compared with 12 other protein kinases. In contrast to other p38 MAPK inhibitors (e.g., SB203580), doramapimod prevents both the kinetic activity and phosphorylation of p38 MAPK by binding to the ATP pocket as well as to a novel allosteric binding site on p38 MAPK.
More Information
Alternate Name/Synonyms
1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea; BRRB 796
SKU
D-2294
CAS #
285983-48-4
Chemical Name
1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea; BRRB 796
Chemical Formula
C31H37N5O3
Molecular Weight
527.66
Appearance
White to off-white Solid
Purity
98% by HPLC
Solubility
DMSO (~50 mg/ml) or EtOH (~ 30 mg/ml)
Storage Temp
-20°C
THERAPEUTIC AREA
Inflammatory Diseases
USE
Doramapimod is a highly selective p38a MAPK inhibitor to TNF-a for active in Crohn's disease
MDL NUMBER
MFCD09752957
CHEMACX
X1511901-0
INCHI
InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
SMILES
Cc1ccc(cc1)n2c(cc(n2)C(C)(C)C)NC(=O)Nc3ccc(c4c3cccc4)OCCN5CCOCC5
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from light and moisture
Handling Protect from light and moisture
UN #'S Not Applicable
Packing Group Not Applicable
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