Doramectin

SKU
D-2529
  • CAS:117704-25-3
  • Formula:C50H74O14
  • MW:899.1
  • Appearance:White solid
  • Purity:>99% by HPLC
Product Name Qty
Doramectin
25 mg
$517.14
Doramectin
5 mg
$148.07
*Please inquire the availability for this product. Doramectin is a biosynthetic avermectin derived from a mutant strain of Streptomyces avermitilis, supplemented with a cyclohexylcaboxylic acid starting unit. Doramectin was developed as an anthelmintic for internal parasite control. The presence of the cyclohexyl group replacing the sec-butyl moiety affords greater hydrophobicity and longer biological half-life compared to avermectin. Like the other milbemycin/avermectins, it selectively binds to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite.
More Information
Alternate Name/Synonyms
Dectomax
SKU
D-2529
CAS #
117704-25-3
Chemical Formula
C50H74O14
Molecular Weight
899.1
Appearance
White solid
Purity
>99% by HPLC
Solubility
Soluble in water (partly), chloroform, and methanol
Melting Point
168 °C
Storage Temp
-20°C
USE
Doramectin is a veterinary drug for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms
MDL NUMBER
MFCD00894747
INCHI
InChI=1S/C50H74O14/c1-27-13-12-16-34-26-57-47-42(51)30(4)21-37(50(34,47)54)48(53)60-36-22-35(63-49(25-36)20-19-29(3)45(64-49)33-14-10-9-11-15-33)18-17-28(2)44(27)61-41-24-39(56-8)46(32(6)59-41)62-40-23-38(55-7)43(52)31(5)58-40/h12-13,16-17,19-21,27,29,31-33,35-47,51-52,54H,9-11,14-15,18,22-26H2,1-8H3/b13-12+,28-17+,34-16+/t27-,29-,31-,32-,35+,36-,37-,38-,39-,40-,41-,42+,43-,44-,45-,46-,47+,49+,50+/m0/s1
SMILES
C[C@H]1/C=C/C=C/2\CO[C@H]3[C@@]2([C@@H](C=C([C@H]3O)C)C(=O)O[C@H]4C[C@@H](C/C=C(/[C@H]1O[C@H]5C[C@@H]([C@H]([C@@H](O5)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O)OC)OC)\C)O[C@]7(C4)C=C[C@@H]([C@H](O7)C8CCCCC8)C)O
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