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Dorsomorphin, DM

SKU
D-1310
  • CAS:866405-64-3
  • Formula:C24H25N5O
  • MW:399.5 Da
  • Appearance:Yellow Solid
  • Purity:≥98%

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CofA
Product Name Qty
Dorsomorphin, AMPK Inhibitor
5 mg
$134.41
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Description

Dorsomorphin is a cell-permeable, potent, selective, reversible and ATP-conmpetitive inhibitor of adenosine monophosphate protein kinase (AMPK) (Ki=109 nM in the presence of ATP and no AMP). It does not display significant inhibition of JAK3, PKA, PKCθ, SYK and ZAPK. The selective compound suppresses fatty acid synthase and food intake in mice. By being competitive with ATP to AMPK, it downregulates the expression of SREBP-1, which is a lipogenic transcription factor, and have hepatocytes produce glucose.

Dorsomorphin also dose-dependently inhibits bone morphogenic protein type I of receptors (BMPR), such as ALK2, ALK3 and ALK6). BMP is required for iron metabolism and embryogenesis. In pluripotent embryonic stem (ES) cells of mice, this compound has been reported to induce cardiomyogenesis robustly. In addition, it also promotes significant neural differentiation in human pluripotent stem cells (hPSC).

 

Application

• Inhibitor of adenosine monophosphate-activated (AMP) protein kinase (AMPK)

• Inhibitor of bone morphogenetic protein (BMP) receptors (BMPR)

• Inhibitor of fatty acid synthase

• Inhibitor of ACTR-1

• Inducer of autophagy

  

References

• “Dorsomorphin, a Selective Small Molecule Inhibitor of BMP Signaling, Promotes Cardiomyogenesis in Embryonic Stem Cells”

• “Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism”

  

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
BML-275; Compound C; AMPK INHIBITOR
SKU
D-1310
CAS #
866405-64-3
Chemical Name
6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Chemical Formula
C24H25N5O
Molecular Weight
399.5 Da
Appearance
Yellow Solid
Purity
≥98%
Solubility
May be dissolved in DMSO (4 mg/mL, warm)
Melting Point
244.93 °C
Storage Temp
-20°C, desiccated, for up to 3 months
THERAPEUTIC AREA
Neurological Disorders
USE
BML-275 is a cell-permeable pyrazolopyrimidine compound shown to be an AMP-activated protein kinase (AMPK) and Fatty Acid Synthase inhibitor. Phosphorylation of AMPK occurs in vivo when energy sources are low and in-turn suppresses expression of SREBP-1. SREBP-1 is a key lipogenic transcription factor, and its suppression allows glucose production by hepatocytes. In mouse studies it has been reported that BML-275 rapidly reduces the level of the phosphorylated AMPK α subunit in the hypothalamus, in an ATP-competitive manner, therefore altering energy perception and affecting the physiological energy sensor of the body. Over-activation of AMPK has also been found to be deleterious in ischemic stroke conditions and inhibition of AMPK by BML-275 may provide a small level of neuroprotection. Additional research on zebrafish has shown that BML-275 also inhibits bone morphogenetic protein signals required for iron metabolism and embryogenesis. BML-275 is an inhibitor of ACTR-I, BMPR-IA and BMPR-IB.
MDL NUMBER
MFCD08705402
CHEMACX
X1561649-0
INCHI
InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2
SMILES
C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product.
msds 1
D-1310, Dorsomorphin, MSDS.pdf
Certificate of Analysis 1
D-1310, J1199L.pdf
Certificate of Analysis 2
D-1310, J1199K.pdf
Certificate of Analysis 3
D-1310, J1199A.pdf
GHS PICTOGRAMS
Handling Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product.
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