SDS
CofA
Description
An irreversible, highly selective cysteine protease inhibitor and cell permeable analog of E-64D. Specifically E-64D is an irreversible cathepsin L and B inhibitor.
E-64d has played an imporant role in studies of the Ebola virus (EBOV). E-64d has been shown to lead to the accumulation of CTFs and AICD with no change ingamma and beta secretase activities. Additionally, utilizing E-64d has shown results in accumulation of autophagic bodies inside vacuoles in Arabidopsis root cells.
References
• http://mbio.asm.org/content/7/1/e01857-15.full.pdf+html
Not for human therapeutic use or for medicinal purposes. For research applications only.
More Information
Alternate Name/Synonyms
E64d; Aloxistatin; Loxistatin
SKU
E-2401
CAS #
88321-09-9
Chemical Name
ethyl (2S,3S)-3-[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylate
Chemical Formula
C17H30N2O5
Molecular Weight
342.43 Da
Appearance
White crystalline powder
Purity
≥98% by HPLC
Solubility
Soluble in EtOH (10 mg/mL) and DMSO (20 mg/mL)
Storage Temp
-20°C
THERAPEUTIC AREA
Neurological Disorders
USE
The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease by inhibiting cathepsin B, but not BACE1, β-secretase activity
MDL NUMBER
MFCD00132883
CHEMACX
X1061801-0
INCHI
InChI=1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1
SMILES
CCOC(=O)[C@@H]1[C@H](O1)C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C
RTECS
RR0404300
Handling
Ensure adequate ventilation, especially in confined areas. Use personal protective equipment as required. Use with local exhaust ventilation. Do not breathe dust/fume/gas/mist/vapors/spray. Handle in accordance with good industrial hygiene and safety practice. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
Certificate of Analysis 1
Certificate of Analysis 2
| GHS PICTOGRAMS |  |
|---|---|
| Handling | Ensure adequate ventilation, especially in confined areas. Use personal protective equipment as required. Use with local exhaust ventilation. Do not breathe dust/fume/gas/mist/vapors/spray. Handle in accordance with good industrial hygiene and safety practice. Corrosive hazard. Wear protective gloves/clothing and eye/face protection. |
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