SDS
CofA
An irreversible, highly selective cysteine protease inhibitor and cell permeable analog of E-64D. Specifically E-64D is an irreversible cathepsin L and B inhibitor.
Most recently e-64D, a pan-cysteine cathepsin inhibitor plays an important role in Ebola virus (EBOV) progression by preventing entry by filoviruses, especially EBOV. E-64d has been shown to lead to the accumulation of CTFs and AICD with no change in gamma and beta secretase activities. Additionally, utilizing E-64d has shown results in accumulation of autophagic bodies inside vacuoles in Arabidopsis root cells.
More Information
Alternate Name/Synonyms
E-64D, E64d
SKU
E-2401
CAS #
88321-09-9
Chemical Name
(2S,3S)-trans-Eepoxysuccinyl-L-Leucylamido-3-methylbutane ethyl ester
Chemical Formula
C17 H30 N2 O5
Molecular Weight
342.43
Appearance
Solid
Solubility
Soluble in ethanol (>10 mg/ml), DMSO (20 mg/ml), DMF (30 mg/ml), and 1:1 DMSO:PBS (pH 7.2) (~0.5 mg/ml). Insoluble in water
Storage Temp
-20°C
THERAPEUTIC AREA
Neurological Disorders
USE
The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease by inhibiting cathepsin B, but not BACE1, β-secretase activity
MDL NUMBER
MFCD00132883
CHEMACX
X1061801-0
INCHI
InChI=1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1
SMILES
CCOC(=O)[C@@H]1[C@H](O1)C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C
RTECS
RR0404300
Certificate of Analysis 1
Certificate of Analysis 2