- Formula:C17 H30 N2 O5
An irreversible, highly selective cysteine protease inhibitor and cell permeable analog of E-64D. Specifically E-64D is an irreversible cathepsin L and B inhibitor.
Most recently e-64D, a pan-cysteine cathepsin inhibitor plays an important role in Ebola virus (EBOV) progression by preventing entry by filoviruses, especially EBOV. E-64d has been shown to lead to the accumulation of CTFs and AICD with no change in gamma and beta secretase activities. Additionally, utilizing E-64d has shown results in accumulation of autophagic bodies inside vacuoles in Arabidopsis root cells.