Elastatinal, Elastase Inhibitor

SKU
E-2044
  • CAS:51798-45-9
  • Formula:C21H36N8O7
  • MW:512.56 Da
  • Appearance:Yellow to off white powder

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Starting at $78.19

Product Name Qty
Elastatinal
5 mg
$78.19
Elastatinal
25 mg
$318.25

Description

Elastatinal is a tetrapeptide derivative with an aldehyde group which is essential for inhibitory activity such as pancreatic elastase. It is a much stronger inhibitor of elastase from pancreas than from leucocytes because it’s isolated from Actinomycetes.

Elastatinal is a highly specific inhibitor of elastase-like serine proteases. Elastatinal can also be used as an inhibitor for thermitase, a thermostable serine protease from Thermoactinomyces vulgaris, and for macroglobulin-protease complexes.

Elastatinal inhibits the proteolytic activity of poliovirus and rhinovirus 2A proteinases in vitro. Additionally, it has no effect on DNA repair and UV-induced sister chromatid exchanges, and inhibits the cleavages found at Ala-Ala bonds in peptides that represent the capsid/nucleocapsid site. Elastatinal is an irreversible inhibitor of neutrophil and rat microglia elastase.

Applications:

• Used as a microbial product inhibitor for elastase
• Ability to reduce rate of degradation of endostain
• Used to effectively inhibit phenylmethylsulfonyl fluoride
Ability to inhibit poliovirus and rhinovirus 2A proteinases in vitro

Specifications

• EC Number: 257-426-7

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
(2S)-2-[(4S)-2-Amino-1,4,5,6-tetrahydro4-pyrimidinyl]-N-[[[(1S)-1- carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-ox
SKU
E-2044
CAS #
51798-45-9
Chemical Name
(2S)-2-[(4S)-2-Amino-1,4,5,6-tetrahydro4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl-L-glutamamide
Chemical Formula
C21H36N8O7
Molecular Weight
512.56 Da
Appearance
Yellow to off white powder
Solubility
Soluble in water up to 20 mg/mL. It has been reported to also be soluble in methanol, pyridine, and dimethyl sulfoxide, and slightly soluble in ethanol.  Alkaline solutions are unstable.
Melting Point
N/A
Preparation
N/A
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
Not Applicable
USE
Elastatinal is a protease inhibitor. Studies have demonstrated that Elastatinal can effectively inhibit phenylmethylsulfonyl fluoride (PMSF, sc-3597) degradation of the H1 histone and high mobility group (HMG) proteins. Elastatinal is an elastase inhibitor and has exhibited the ability to inhibit poliovirus and rhinovirus 2A proteinases in vitro. Additionally, it has no effect on DNA repair and UV-induced sister chromatid exchanges, and inhibits the cleavages found at Ala-Ala bonds in peptides that represent the capsid/nucleocapsid site. Elastatinal is an inhibitor of Neutrophil Elastase.
Merck Index
N/A
MDL NUMBER
MFCD00151180
CHEMACX
X1089720-8
PubChecm ID
3211
INCHI
InChI=1S/C21H36N8O7/c1-10(2)8-14(19(34)35)28-21(36)29-16(12-6-7-24-20(23)27-12)18(33)26-13(4-5-15(22)31)17(32)25-11(3)9-30/h9-14,16H,4-8H2,1-3H3,(H2,22,31)(H,25,32)(H,26,33)(H,34,35)(H3,23,24,27)(H2,28,29,36)
SMILES
CC(C)CC(C(=O)O)NC(=O)NC(C1CCN=C(N1)N)C(=O)NC(CCC(=O)N)C(=O)NC(C)C=O
RTECS
LZ9600000
Handling
Keep dry. Freeze upon arrival. Protect from light. Handle in accordance with good industrial hygiene and safety practice.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
Handling Keep dry. Freeze upon arrival. Protect from light. Handle in accordance with good industrial hygiene and safety practice.
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