Emetine dihydrochloride

SKU

E-2304

CAS:316-42-7
Formula:C₂₉H₄₀N₂O₄
MW:553.56
Appearance:White to off-white Solid
Purity:98% by titration

SDS

CofA

Product Name	Qty
Emetine dihydrochloride 50 mg $72.59
Emetine dihydrochloride 250 mg $290.35

Details

A bitter-tasting crystalline alkaloid,derived from ipecac root and used in the treatment of amebiasis and as an emetic.Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Also, selectively inhibits multiple glioblastoma (GBM) stem cells-enriched cultures.

Specifications

More Information

Alternate Name/Synonyms

2S,3R,11bS)-2-{[(1R)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline

SKU

E-2304

CAS #

316-42-7

Chemical Name

2S,3R,11bS)-2-{[(1R)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline

Chemical Formula

C₂₉H₄₀N₂O₄

Molecular Weight

553.56

Appearance

White to off-white Solid

Purity

98% by titration

Solubility

Soluble in Water (~ 100 mg/ml)

Storage Temp

+4°C

THERAPEUTIC AREA

Infectious Diseases

USE

Used in the treatment of amebiasis and as an emetic

MDL NUMBER

MFCD00135589

CHEMACX

X1005305-1

INCHI

InChI=1S/C29H40N2O4.2ClH/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H/t18-,21-,24+,25-;;/m0../s1

SMILES

CC[C@H]1CN2CCc3cc(c(cc3[C@@H]2C[C@@H]1C[C@@H]4c5cc(c(cc5CCN4)OC)OC)OC)OC.Cl.Cl

Peptide sequence

Not Applicable

RTECS

JY5250000

UN #'S

UN 1544

PACKING GROUP

HAZARD CLASS

Not Applicable

Handling