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Emetine dihydrochloride

SKU
E-2304
  • CAS:316-42-7
  • Formula:C29H40N2O4 • 2HCl
  • MW:553.56 Da
  • Appearance:White to off-white solid
  • Purity:≥98% by titration

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SDS
CofA
Product Name Qty
Emetine dihydrochloride
50 mg
$84.00
Emetine dihydrochloride
250 mg
$319.00
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Description

Emetine dihydrochloride is a crystalline alkaloid derived from ipecac root and is used as an amebicide and emetic. It inhibits protein synthesis by binding to the 40S subunit of ribosomes along the mRNA. The alkaloid induces hypotension by blocking adrenoreceptors and inhibits DNA replication in the early S phase.

In addition, it suppresses specific HIF-1 by affecting its protein stability and transcriptional activity. It is also reported that the emetine dihydrochloride induces apoptosis in leukemia cell lines and inhibits tumor cell growth in bladder cancer cells.

Emetine is a potential antiviral. One research study reported that it potently inhibits dengue virus infections at an early stage of the viral replication cycle. It has also been shown to inhibit coronavirus replication. It is reported that it is synergistic when remdesivir is used for SARS-CoV-2. In a recent study, it was shown that concentrations of emetine could be almost 300 times higher in the lungs even though they were achievable in the blood. Because it is an anti-coronavirus agent, it may be a potential antiviral for COVID-19.

 

Applications

• Amebicide

• Emetic

• Antiviral agent

• Anticancer agent

 

References

• “Antiviral Activity of Emetine Dihydrochloride Against Dengue Virus Infection”

• “Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro”

• “Emetine, Ipecac, Ipecac Alkaloids and Analogues as Potential Antiviral Agents for Coronaviruses”

• “Emetine Dihydrochloride: A Novel Therapy for Bladder Cancer”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Emetine hydrochloride; Amebicide; Purum; Emetine HCl
SKU
E-2304
CAS #
316-42-7
Chemical Name
(2S,3R,11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizine;dihydrochloride
Chemical Formula
C29H40N2O4 • 2HCl
Molecular Weight
553.56 Da
Appearance
White to off-white solid
Purity
≥98% by titration
Solubility
Soluble in water (~ 100 mg/mL)
Storage Temp
4°C
THERAPEUTIC AREA
Infectious Diseases
USE
Used in the treatment of amebiasis and as an emetic
MDL NUMBER
MFCD00135589
CHEMACX
X1005305-1
INCHI
InChI=1S/C29H40N2O4.2ClH/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H/t18-,21-,24+,25-;;/m0../s1
SMILES
CC[C@H]1CN2CCc3cc(c(cc3[C@@H]2C[C@@H]1C[C@@H]4c5cc(c(cc5CCN4)OC)OC)OC)OC.Cl.Cl
Peptide sequence
Not Applicable
RTECS
JY5250000
UN #'S
UN 1544
PACKING GROUP
I
Handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Protect from light and moisture.
Certificate of Analysis 1
E-2304, L1132.pdf
GHS PICTOGRAMS
Handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Protect from light and moisture.
UN #'S UN 1544
Packing Group I
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