Emetine dihydrochloride

SKU
E-2304
  • CAS:316-42-7
  • Formula:C29H40N2O4
  • MW:553.56
  • Appearance:White to off-white Solid
  • Purity:98% by titration

4

0

0

0

Product Name Qty
Emetine dihydrochloride
50 mg
$72.59
Emetine dihydrochloride
250 mg
$290.35
A bitter-tasting crystalline alkaloid,derived from ipecac root and used in the treatment of amebiasis and as an emetic.Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Also, selectively inhibits multiple glioblastoma (GBM) stem cells-enriched cultures.
More Information
Alternate Name/Synonyms
2S,3R,11bS)-2-{[(1R)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline
SKU
E-2304
CAS #
316-42-7
Chemical Name
2S,3R,11bS)-2-{[(1R)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline
Chemical Formula
C29H40N2O4
Molecular Weight
553.56
Appearance
White to off-white Solid
Purity
98% by titration
Solubility
Soluble in Water (~ 100 mg/ml)
Storage Temp
+4°C
THERAPEUTIC AREA
Infectious Diseases
USE
Used in the treatment of amebiasis and as an emetic
MDL NUMBER
MFCD00135589
CHEMACX
X1005305-1
INCHI
InChI=1S/C29H40N2O4.2ClH/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H/t18-,21-,24+,25-;;/m0../s1
SMILES
CC[C@H]1CN2CCc3cc(c(cc3[C@@H]2C[C@@H]1C[C@@H]4c5cc(c(cc5CCN4)OC)OC)OC)OC.Cl.Cl
Peptide sequence
Not Applicable
RTECS
JY5250000
UN #'S
UN 1544
PACKING GROUP
I
HAZARD CLASS
Not Applicable
Handling
Protect from light and moisture
GHS PICTOGRAMS
Handling Protect from light and moisture
UN #'S UN 1544
Packing Group I
To Top