Enzastaurin

SKU
E-2048
  • CAS:170364-57-5
  • Formula:C32H29N5O2
  • MW:515.61
  • Appearance:Solid
  • Purity:99%
Product Name Qty
Enzastaurin
1 mg
$329.44
Enzastaurin
5 mg
$999.48

Enzastaurin (Enz) is a potent and selective inhibitor of PKC with antiproliferative activity (IC= ~6 nM). Binding to the ATP-binding site, enzastaurin selectively inhibits Protein kinase & protein kinase C beta. Enz suprpresses VEGF-induced angiogenesis in the rat corneal micropocket assay, decreases microvessel density, and prevents VEGF secretion from human tumor cell xenografts in nude mice. Prolonged courses of Enz increase chemotherapy or radiation tumor growth delay of glioma, breast, and small cell lung cancer xenografts.

More Information
Alternate Name/Synonyms
LY317615
SKU
E-2048
CAS #
170364-57-5
Chemical Name
3-(1-METHYLINDOL-3-YL)-4-[1-[1-(PYRIDIN-2-YLMETHYL)PIPERIDIN-4-YL]INDOL-3-YL]PYRROLE-2,5-DIONE
Chemical Formula
C32H29N5O2
Molecular Weight
515.61
Appearance
Solid
Purity
99%
Solubility
DMSO
Storage Temp
Keep cool and dry. Store at -20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Enzastaurin is a synthetic bisindolylmaleimide with potential antineoplastic activity
MDL NUMBER
MFCD11040980
CHEMACX
X1722797-7
INCHI
InChI=1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31(29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7-15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39)
SMILES
Cn1cc(c2c1cccc2)C3=C(C(=O)NC3=O)c4cn(c5c4cccc5)C6CCN(CC6)Cc7ccccn7
Handling
Do not take internally. Wear gloves and mask when handling the product.Avoid contact by all modes of exposure.
Promo text for AGS discount
N/A
GHS PICTOGRAMS
Handling Do not take internally. Wear gloves and mask when handling the product.Avoid contact by all modes of exposure.
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