Epothilone B

SKU
E-2449
  • CAS:152044-54-7
  • Formula:C27H4NO6S
  • MW:507.7
  • Appearance:White to off white powder
  • Purity:>98% by HPLC
Product Name Qty
Epothilone B
1 mg
$41.74
Epothilone B
5 mg
$160.69
*Please inquire the availability for this product. Epothilone B is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Like epothilone A, epothilone B acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity.
More Information
Alternate Name/Synonyms
EpoB
SKU
E-2449
CAS #
152044-54-7
Chemical Formula
C27H4NO6S
Molecular Weight
507.7
Appearance
White to off white powder
Purity
>98% by HPLC
Solubility
Soluble in Chloroform, Dichloromethane, DMSO, Ethanol and Methanol
Melting Point
95-97°C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Epo B causes cell cycle arrest in cell lines from ovarian, breast, lung, colon, prostate, and squamous cancer.
MDL NUMBER
MFCD02101921
INCHI
InChI=1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
SMILES
Cc1nc(cs1)/C=C(\C)/[C@@H]2C[C@H]3[C@](O3)(CCC[C@@H]([C@@H]([C@H](C(=O)C([C@H](CC(=O)O2)O)(C)C)C)O)C)C
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