EPZ005687

SKU

E-2509

CAS:1396772-26-1
Formula:C₃₂H₃₇N₅O₃
MW:539.67
Appearance:white powder
Purity:≥99%

SDS

CofA

Product Name	Qty
EPZ005687 5 mg $87.52
EPZ005687 25 mg $291.72
EPZ005687 100 mg $875.16
EPZ005687 1 mg $44.88

Details

EPZ-005687 is a highly selective inhibitor of mutant EZH2, a histone methyltransferase (HMT) that exhibits point mutations at key residues Tyr641 and Ala677 in non-Hodgkin’s lymphoma and other cancers. EPZ-005687 displays anticancer chemotherapeutic activity through its inhibition of EZH2; this enzyme is responsible for methylation of lysine and arginine residues and controls gene transcription fidelity in cells. Inhibition of mutant EZH2 induces apoptosis.

Specifications

More Information

Alternate Name/Synonyms

1-cyclopentyl-N-[(4, 6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-[4-(morpholin-4-ylmethyl) phenyl]indazole-4-carboxamide

SKU

E-2509

CAS #

1396772-26-1

Chemical Formula

C₃₂H₃₇N₅O₃

Molecular Weight

539.67

Appearance

white powder

Purity

≥99%

Solubility

DMSO

Storage Temp

-20°C

Hazard Image

Yes

Reviews

Safety

Citations