EPZ005687
SKU
E-2509
- CAS:1396772-26-1
- Formula:C32H37N5O3
- MW:539.67
- Appearance:white powder
- Purity:≥99%
SDS
CofA
EPZ-005687 is a highly selective inhibitor of mutant EZH2, a histone methyltransferase (HMT) that exhibits point mutations at key residues Tyr641 and Ala677 in non-Hodgkin’s lymphoma and other cancers. EPZ-005687 displays anticancer chemotherapeutic activity through its inhibition of EZH2; this enzyme is responsible for methylation of lysine and arginine residues and controls gene transcription fidelity in cells. Inhibition of mutant EZH2 induces apoptosis.
More Information
Alternate Name/Synonyms
1-cyclopentyl-N-[(4, 6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-[4-(morpholin-4-ylmethyl) phenyl]indazole-4-carboxamide
SKU
E-2509
CAS #
1396772-26-1
Chemical Formula
C32H37N5O3
Molecular Weight
539.67
Appearance
white powder
Purity
≥99%
Solubility
DMSO
Storage Temp
-20°C
Hazard Image
Yes