Erlotinib Hydrochloride Salt

SKU
E-2307
  • CAS:183319-69-9
  • Formula:C22H23N3O4.HCl
  • MW:429.9
  • Appearance:White to off-white Solid
  • Purity:99% by HPLC
Product Name Qty
Erlotinib Hydrochloride Salt
100 mg
$108.21
Erlotinib Hydrochloride Salt
1 g
$336.03

Erlotinib is an inhibitor of human Epidermal growth factor receptor (EGFR) tyrosine kinase (IC= 2 nM) and decreases EGFR autophosphorylation in tumor cells (IC= 20 nM). Studies in cell lines and enzyme assays have both shown that erlotinib inhibits EGFR at concentrations significantly lower than those needed to inhibit c-src and v-abl.

More Information
Alternate Name/Synonyms
CP-358774, OSI-774
SKU
E-2307
CAS #
183319-69-9
Chemical Name
N-(3-ETHYNYLPHENYL)-6,7-BIS(2-METHOXYETHOXY)QUINAZOLIN-4-AMINE HYDROCHLORIDE
Chemical Formula
C22H23N3O4.HCl
Molecular Weight
429.9
Appearance
White to off-white Solid
Purity
99% by HPLC
Solubility
DMSO
Melting Point
223-225 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
An HER-1/EGFR tyrosine kinase inhibitor used to treat non-small cell lung cancer (NSCLC), pancreatic cancer
MDL NUMBER
MFCD07781272
CHEMACX
X1511913-0
INCHI
InChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H
SMILES
COCCOc1cc2c(cc1OCCOC)ncnc2Nc3cccc(c3)C#C.Cl
UN #'S
UN 3077
PACKING GROUP
III
Handling
Protect from light and moisture
GHS PICTOGRAMS
HandlingProtect from light and moisture
UN #'SUN 3077
Packing GroupIII
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