SDS
CofA
Description
Erythromycin B (12-deoxyerythromycin) is a minor co-metabolite of erythromycin produced Saccharopolyspora erythreae. Erythromycin B exhibits broad spectrum antibiotic activity, albeit less potent than erythromycin A. Erythromycin B played an integral part of the SAR studies of semi-synthetic erythromycins, however none reached clinical development.
More Information
Alternate Name/Synonyms
12-Deoxyerythromycin; Berythromycin; Beritromicina; Berythromycine; Berythromycinum
SKU
E-2471
CAS #
527-75-3
Chemical Name
(3R,4S,5S,6R,7R,9R,11R,12S,13R,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
Chemical Formula
C37H67NO12
Molecular Weight
717.9 Da
Appearance
White solid
Purity
>98% by HPLC
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Good water solubility
Storage Temp
-20°C
THERAPEUTIC AREA
Infectious Diseases
USE
A minor co-metabolite that exhibits broad spectrum antibiotic activity
MDL NUMBER
MFCD01729130
INCHI
InChI=1S/C37H67NO12/c1-14-26-20(4)29(40)21(5)28(39)18(2)16-36(9,44)33(50-35-30(41)25(38(11)12)15-19(3)46-35)22(6)31(23(7)34(43)48-26)49-27-17-37(10,45-13)32(42)24(8)47-27/h18-27,29-33,35,40-42,44H,14-17H2,1-13H3/t18-,19-,20+,21+,22+,23-,24+,25+,26-,27+,29+,30-,31+,32+,33-,35+,36-,37-/m1/s1
SMILES
CC[C@@H]1[C@@H]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)O)C
Handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
| GHS PICTOGRAMS |  |
|---|---|
| Handling | Avoid contact with skin and eyes. Avoid formation of dust and aerosols. |
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