Ethacrynic acid, GST Inhibitor-2

SKU
G-2345
  • CAS:58-54-8
  • Formula:C13H12CI2O4
  • MW:303.14 Da
  • Appearance:White to off-white powder
  • Purity:99%

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Product Name Qty
Ethacrynic acid, GST Inhibitor-2
1 g
$54.99
Ethacrynic acid, GST Inhibitor-2
5 g
$209.99
Ethacrynic acid, GST Inhibitor-2
10 g
$399.99

Description

Ethacrynic acid is a highly effective diuretic that acts by inhibiting the sodium-potassium-chloride symporter protein in the human kidney. This effect occurs primarily in the ascending limb of the loop of Henle but also occurs to a lesser degree in the distal and proximal tubules. It is also a documented inhibitor of glutathione S-transferases (GSTs). This acid is an unsaturated ketone derived from aryloxyacetic acid.

Applications

Ethacrynic acid sees widespread use in clinical medicine due to its diuretic properties. Various edema disorders can be treated with ethacrynic acid, including those associated with congestive heart failure, renal disease and liver failure. As a rule, it is administered in cases that call for a very potent diuretic, while less powerful diuretics are used for less severe cases.

Ethacrynic acid has also been studied for a variety of other uses and continues to be a target of research. Studies have shown that the acid can promote apoptosis in certain leukemia and lymphoma cells by suppressing GSTP1-1.

 

Specifications

EC Number: 200-384-1

CHEBI: 4876

More Information
Alternate Name/Synonyms
Etacrynic Acid; Ethacrynate; Etacrinic acid; Hydromedin; Edecrin; Crinuryl; Edecril; Edecrina; Endecril; Hidromedin; Otacril; Taladren; Mingit; Reomax; Uregit; Methylenebutyrylphenoxyacetic acid
SKU
G-2345
CAS #
58-54-8
Chemical Name
2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid
Chemical Formula
C13H12CI2O4
Molecular Weight
303.14 Da
Appearance
White to off-white powder
Purity
99%
Solubility
Soluble in DMSO.
Melting Point
124-126 °C
Preparation
N/A
Storage Temp
Room temperature
THERAPEUTIC AREA
Nephrological Disorders
USE
Ethacrynic acid, GST Inhibitor-2 is a compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, and also in the proximal and distal tubules.
Merck Index
N/A
MDL NUMBER
MFCD00056693
CHEMACX
X1004263-4
PubChecm ID
329825461
INCHI
InChI=1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)
SMILES
CCC(=C)C(=O)c1ccc(c(c1Cl)Cl)OCC(=O)O
Peptide sequence
Not Applicable
RTECS
AG6600000
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from light and moisture. Harmful if swallowed, in contact with skin or if inhaled. Causes skin irritation.Causes serious eye irritation. May cause respiratory irritation.
Certificate of Analysis 1
Certificate of Analysis 2
GHS PICTOGRAMS
Handling Protect from light and moisture. Harmful if swallowed, in contact with skin or if inhaled. Causes skin irritation.Causes serious eye irritation. May cause respiratory irritation.
UN #'S Not Applicable
Packing Group Not Applicable
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