Eicosatetraynoic acid (ETYA)

  • CAS:1191-85-1
  • Formula:C20H4O2
  • MW:296.5 Da
  • Appearance:White to off-white solid
  • Purity:≥98%
Product Name Qty
Eicosatetraynoic acid (ETYA)
5 mg
Eicosatetraynoic acid (ETYA)
25 mg
Eicosatetraynoic acid (ETYA)
100 mg


The peroxisome proliferator-activated receptor (PPAR)-α activator, 5,8,11,14-eicosatetraynoic acid (ETYA), is an arachidonic acid analog. It is reported to inhibit up-regulation of pro-inflammatory genes. Among the inflammatory chemokines elaborated, glial cell-derived CCL2/MCP-1 is crucial, it promotes the migration and recruitment of inflammatory cells, it is primarily responsible for the initiation and progression of inflammatory responses in neurodegenerative disease and also associated with a variety of disease, including atherosclerosis.

ETYA has an anti-inflammatory mechanism, by increasing HuR-mediated-MKP-1 mRNA stability that leads to the specific suppression of CCL2/MCP-1 during inflammatory processes. Studies have shown that ETYA increases MKP-1 expression through HuR at the post-transcriptional level in a receptor-independent manner. Thereby providing evidence that ETYA is a potential therapeutic modulator of inflammation. ETYA's influence on suppressing CCL2/MCP-1 expression is an emerging therapeutic strategy for the treatment of neurodegenerative diseases such as Alzheimer's disease, multiple sclerosis, and brain ischemia.

A recent research regarding upper aerodigestive cancer ( an aggressive malignancy) has revealed that PPARγ pathways would be a novel therapy for this cancer. ETYA is a PPARγ activator and results from this study have shown that it down regulates cell proliferation and has antineoplastic features.


More Information
Alternate Name/Synonyms
eicosatetranoic acid; 5,8,11,14-eicosatetraynoic acid; icosa-5,8,11,14-tetraynoic acid; Octadehydroarachidonic acid
Chemical Name
icosa-5,8,11,14-tetraynoic acid
Chemical Formula
Molecular Weight
296.5 Da
White to off-white solid
Soluble in ethanol, methanol, or DMSO.
Storage Temp
Handle in accordance with good industrial hygiene and safety practice.
SUSCEPTIBILITY: Potent In Vitro Antifungal Activities of Naturally Occurring Acetylenic Acids Xing-Cong Li, Melissa R. Jacob, Shabana I. Khan, M. Khalid Ashfaq, K. Suresh Babu, Ameeta K. Agarwal, Hala N. ElSohly, Susan P. Manly, and Alice M. Clark Antimicrob. Agents Chemother., Jul 2008; 52: 2442 - 2448.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
HandlingHandle in accordance with good industrial hygiene and safety practice.
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