EX-527

SKU
C-1445
  • CAS:49843-98-3
  • Formula:C13H13ClN2O
  • MW:248.7
  • Appearance:White to Tan Powder
  • Purity:95%

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Product Name Qty
EX-527
1 mg
$134.01
Specific cell permeable inhibitor. Potent cell permeable and metabolically stable specific inhibitor of hSIRT1 (IC=98nM in vivo / IC=38nM in vitro; compared to hSIRT2: IC=19M and hSIRT3: IC=48M) with no effect on human histone deacetylases (HDACs) class I and class II, nor NAD glycohydrolase (IC100g). Inhibits the deacetylation of p53 (IC=1M).
More Information
Alternate Name/Synonyms
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
SKU
C-1445
CAS #
49843-98-3
Chemical Name
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Chemical Formula
C13H13ClN2O
Molecular Weight
248.7
Appearance
White to Tan Powder
Purity
95%
Solubility
Soluble in DMSO (10mg/ml).
Storage Temp
-20°C
THERAPEUTIC AREA
Neurological Disorders
USE
A selective inhibitor of SIRT1 over SIRT2 and SIRT3 for the Treatment of Huntington’s Disease
MDL NUMBER
MFCD03009471
CHEMACX
X1520276-1
INCHI
InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)
SMILES
c1cc2c(cc1Cl)c3c([nH]2)C(CCC3)C(=O)N
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
UN 2811
PACKING GROUP
III
HAZARD CLASS
Not Applicable
Handling
Store in Tightly sealed Vial Protect from Light
Certificate of Analysis 1
GHS PICTOGRAMS
Handling Store in Tightly sealed Vial Protect from Light
UN #'S UN 2811
Packing Group III
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