Favipiravir

SKU
F-1200
  • CAS:259793-96-9
  • Formula:C5H4FN3O2
  • MW:157.1 Da
  • Appearance:Off-white powder
  • Purity:>99% by HPLC
Product Name Qty
Favipiravir
5 mg
$75.00
Favipiravir
25 mg
$299.99

Description

Favipiravir is an inhibitor of influenza viruses A, B, and C (IC50s: A = 0.03- 0.20 µg/mL H1N1; 0.01-0.30 H2N2; 0.08-0.48 H3N2; 0.14-0.15 H4N2; 0.24-1.60 H7N2; 0.20-0.82 H5N1; 0.35 H1N2; B = 0.04-0.09 µg/mL; C = 0.03-0.06 µg/mL) as well as strains resistant to adamantane-type antivirals, oseltamivir, and zanamivir1-3 . It displays no cytotoxicity in a variety of cell lines. Selectively inhibits viral RNA-dependent RNA polymerase4 . Displays activity against other viruses including arena, phlebo, hanta, flavi, entero, alpha, respiratory syncytial, and noroviruses5 . In clinical trials for treatment of SARS-CoV-26,7.

 

References

"In Vitro and In Vivo Activities of Anti-Influenza Virus Compound T-705"

"Broad spectrum anti-RNA virus activities of titanium and vanadium substituted polyoxotungstates"

"In Vitro Antiviral Activity of Favipiravir (T-705) against Drug-Resistant Influenza and 2009 A(H1N1) Viruses"

"Mechanism of Action of T-705 against Influenza Virus"

"Favipiravir (T-705), a novel viral RNA polymerase inhibitor"

"Discovering drugs to treat coronavirus disease 2019 (COVID-19)"

"A Review of SARS-CoV-2 and the Ongoing Clinical Trials"

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
6-Fluoro-3-hydroxypyrazine-2-carboxamide; T-705
SKU
F-1200
CAS #
259793-96-9
Chemical Name
5-fluoro-2-oxo-1H-pyrazine-3-carboxamide
Chemical Formula
C5H4FN3O2
Molecular Weight
157.1 Da
Appearance
Off-white powder
Purity
>99% by HPLC
Solubility
May be dissolved in DMSO (30 mg/mL); or water (12 mg/mL with warming)
Storage Temp
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.
THERAPEUTIC AREA
Infectious diseases
USE
Treatment of viral infections. Clinical trials for treatment of SARS-CoV-2, COVID-19.
Handling
Avoid contact with skin and eyes. Ventilation and proper handling are to be used to prevent the formation of dusts and mists. Normal measures for preventative fire protection. No smoking, eating or drinking around this material. Wash hands after use.
Hazard Image
Yes
GHS PICTOGRAMS
Handling Avoid contact with skin and eyes. Ventilation and proper handling are to be used to prevent the formation of dusts and mists. Normal measures for preventative fire protection. No smoking, eating or drinking around this material. Wash hands after use.
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