Filipin complex, anti-fungal agent
- Formula:C35H58O11 (for Flipin III)
- MW:654.8 Da
- Appearance:Yellow solid
- Purity:>95% by HPLC
Filipin complex comprises a family of pentaene macrocyclic lactones first isolated from Streptomyces filipinensis and reported by researchers at Upjohn in 1955. Filipin complex consists of four analogues, with filipin III comprising the bulk (>70%) of the complex. Filipin complex is a potent broad spectrum antifungal agent that also exhibits antitumor and antiviral activities. Filipin complex acts by binding cell membrane sterols, and disrupting the membrane integrity. Inhibits mitochondrial respiration.
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