FK-866

SKU
F-2328
  • CAS:658084-64-1
  • Formula:C24H29N3O2
  • MW:391.51
  • Appearance:White to off-white Solid
  • Purity:98% by NMR
Product Name Qty
FK-866
5 mg
$104.86
FK-866
1 mg
$71.75
Cell-permeable. FK-866 is a highly specific non-competitive inhibitor of Nicotinamide phosphoribosyltransferase (NAMPT) (K = 0.4 nM), causing gradual NAD+ depletion. NAMPT functions as an intra-cellular and extra-cellular NAD biosynthetic enzyme that is important for regulating metabolism and stress resistance through sirtuins and other NAD-consuming regulators. NAD+ depletion by FK-866 directs delayed cell death by apoptosis in Hep-G2 human liver carcinoma cells
More Information
Alternate Name/Synonyms
N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide
SKU
F-2328
CAS #
658084-64-1
Chemical Name
N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide
Chemical Formula
C24H29N3O2
Molecular Weight
391.51
Appearance
White to off-white Solid
Purity
98% by NMR
Solubility
Soluble in DMSO (30 mg/ml) and Ethanol
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
FK-866 has been shown to induce apoptosis by non-competitive, and specific inhibition of nicotamide phosphoribosyltransferase (NAMPT)
MDL NUMBER
MFCD10565943
CHEMACX
X1759584-7
INCHI
InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+
SMILES
C1CN(CCC1CCCCNC(=O)/C=C/C2=CN=CC=C2)C(=O)C3=CC=CC=C3
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from light and air
HandlingProtect from light and air
UN #'SNot Applicable
Packing GroupNot Applicable
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