Floxuridine (FUDR)
SKU
F-2447
- CAS:50-91-9
- Formula:C9H11FN2O5
- MW:246.20 Da
- Appearance:White or almost white crystalline powder
- Purity: ≥ 98.5 % HPLC
SDS
CofA
Description
Floxuridine is a pyramidine analogue that acts as an antineoplastic antimetabolite. Floxuridine inhibits cell division by inhibiting thymidylate formation, which in turn prevents the formation of dTTP. Via this mechanism, floxuridine exerts an anti-cancer effect.
Applications
In clinical oncology, floxuridine is a preferred drug for the treatment of cancers of the colon which have metastasized to the liver. For this purpose, it is typically administered via the hepatic artery. Administration often occurs in conjunction with folinic acid, which enhances the drug's effects. In research, it is primarily used in studies of liver cancers and their treatments, as well as in ongoing studies on the mechanisms of chemotherapeutic drugs.
More Information
Alternate Name/Synonyms
Fluorodeoxyuridine; FUDR; Floxuridin; Deoxyfluorouridine; FdUrd; Floxiridina; Floxuridinum
SKU
F-2447
CAS #
50-91-9
Chemical Name
5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
Chemical Formula
C9H11FN2O5
Molecular Weight
246.20 Da
Appearance
White or almost white crystalline powder
Purity
≥ 98.5 % HPLC
Solubility
Water, DMF, DMSO
Melting Point
145 – 147 ºC
Storage Temp
20°C, desiccated
THERAPEUTIC AREA
Oncological treatment
USE
Floxuridine (FUDR) is shown to have activity against a variety of malignant neoplasms, including mouse mammary tumors and colorectal carcinomas. 5-Fluoro-2'-deoxyuridine is an inhibitor of TS. It has been used as a mitotic inhibitor in schwann cell proliferation, glia proliferation and nonneuronal cells in dorsal root ganglion cultures.
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
Certificate of Analysis 1
| GHS PICTOGRAMS |
|
|---|---|
| Handling | Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation. Corrosive hazard. Wear protective gloves/clothing and eye/face protection. |
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