
Description
Forskolin is a cell-permeable labdane diterpene derived from Coleus Forskohlii which directly stimulates adenylate cyclase (AC). This unique diterpene increases in levels of intracellular cyclic AMP (cAMP) from ATP in various eukaryotic cells by activating AC. cAMP is a second messenger mediating a variety of signaling pathways and is related to lipolysis via thermogenesis. It is reported that forskolin induces CYP3A gene expression in primary hepatocytes by functioning as agonists of the pregnane X receptor (PXR). Protein kinase A (PKA) signal transduction pathway activated by cAMP enhances CYP3A gene expression induced by PXR.
This compound is a potent inhibitor of platelet aggregation and proven for antitumor effects. cAMP signaling related to forskolin is relevant to the effects in induction of mesenchymal-to-epithelial transition, inhibition of cell proliferation and metastasis. In addition, it helps sensitivity to antitumor drugs enhanced in cancer cells.
The natural compound is also inotropic and has been used for hypertension and respiratory disorders as well.
Applications
• Study for signaling pathway
• Study for antitumor drug
• Inotropic agent
Additional Reading
• AGS Blog: Forskolin for Weight Loss - A Natural Remedy!
References
• “Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?”
• “Forskolin: a unique diterpene activator of cyclic AMP-generating systems”
• “Forskolin: A potential antimetastatic agent”
• “The Natural cAMP Elevating Compound Forskolin in Cancer Therapy: Is It Time?”
• “A New Potential Weapon for Fighting Obesity: Forskolin—the Active Diterpene in Coleus”
Not for human therapeutic use or for medicinal purposes. For research applications only.
GHS PICTOGRAMS | ![]() |
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Handling | Avoid contact with skin, eyes, and personal clothing. Wash hands thoroughly after handling. Avoid breathing fumes. Use only with adequate ventilation. Wear suitable protective clothing, gloves, and eye/face protection. Keep away from sources of ignition. Minimize dust generation and accumulation. Keep container tightly closed. Open and handle container with care. Do not eat, drink, or smoke while handling. |
UN #'S | Not Applicable |
Packing Group | Not Applicable |