Forskolin

SKU
F-1026
  • CAS:66575-29-9
  • Formula:C22H34O7
  • MW:410.5 Da
  • Appearance:White crystalline solid
  • Purity:≥99%

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Product Name Qty
Forskolin
10 mg
$81.16
Forskolin
25 mg
$124.45
Forskolin
100 mg
$270.53

Forskolin is an extract from the root of Coleus Forskohlii.  C. Forskholii, is a member of the mint family of plants. Forskolin acts directly on adenylate cyclase, an enzyme that activates the synthesis of cyclic adenosine monophosphate (cAMP) in the cell. cAMP promotes the breakdown of stored fats in animal and human fat cells. In vitro and animals studies have shown forskolin and its derivative can inhibit cell proliferation, and induce cell cycle arrest and apoptosis in human gastric cancer cells. Forskolin was also found to inhibit melanoma cell-induced platelet aggregation and reduce lung metastasis. Forskolin upregulates the expression of cytochrome P450 3A (CYP3A) family through the pregnane-X-receptor that regulates the CYP3A genes.

It is used for a variety of conditions, including cancer, obesity, glaucoma, asthma, and heart failure. Small clinical studies suggest that forskolin can benefit obese men in weight management. When applied on the skin of mice, forskolin can stimulate the production of melanin in the absence of ultraviolet light. It has been proposed for use in sunless tanning lotions to reduce the risk of skin cancer by decreasing exposure to sun.

More Information
Alternate Name/Synonyms
Colforsin; Coleonol; colforsina; colforsine; colforsinum; Boforsin; Coleonolk
SKU
F-1026
CAS #
66575-29-9
Chemical Name
[(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate
Chemical Formula
C22H34O7
Molecular Weight
410.5 Da
Appearance
White crystalline solid
Purity
≥99%
Solubility
May be dissolved in DMSO (160 mg/mL) or Ethanol (50mg/mL)
Storage Temp
-20°C, desiccated, store up to 4 months.
THERAPEUTIC AREA
Cardiological Disorders
USE
Forskolin is commonly used as a tool in biochemistry to raise levels of cyclic AMP (cAMP) in the study and research of cell physiology. Forskolin activates the enzyme adenylyl cyclase and increases intracellular levels of cAMP. cAMP is an important second messenger necessary for the proper biological response of cells to hormones and other extracellular signals.
Merck Index
Merck Index: 13.2500.2001
MDL NUMBER
MFCD00082317
CHEMACX
X1009715-3
INCHI
InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
SMILES
CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O
Peptide sequence
Not Applicable
RTECS
QL6150000
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Avoid contact with skin, eyes, and personal clothing. Wash hands thoroughly after handling. Avoid breathing fumes. Use only with adequate ventilation. Wear suitable protective clothing, gloves, and eye/face protection. Keep away from sources of ignition. Minimize dust generation and accumulation. Keep container tightly closed. Open and handle container with care. Do not eat, drink, or smoke while handling.
msds 1
/media/upload/pdf/F-1026, Forskolin, SDS, diamond format.pdf
Certificate of Analysis 1
/media/upload/pdf/F-1026, H1258C.pdf
Certificate of Analysis 2
/media/upload/pdf/F-1026, H1258B.pdf
Certificate of Analysis 3
/media/upload/pdf/F-1026, H1258A.pdf
GHS PICTOGRAMS
Handling Avoid contact with skin, eyes, and personal clothing. Wash hands thoroughly after handling. Avoid breathing fumes. Use only with adequate ventilation. Wear suitable protective clothing, gloves, and eye/face protection. Keep away from sources of ignition. Minimize dust generation and accumulation. Keep container tightly closed. Open and handle container with care. Do not eat, drink, or smoke while handling.
UN #'S Not Applicable
Packing Group Not Applicable
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