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Forskolin

SKU
F-1026
  • CAS:66575-29-9
  • Formula:C22H34O7
  • MW:410.5 Da
  • Appearance:White crystalline solid
  • Purity:≥99%

Starting at $82.78

Product Name Qty
Forskolin
25 mg
$126.94
Forskolin
100 mg
$275.94
Forskolin
10 mg
$82.78
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Description

Forskolin is a cell-permeable labdane diterpene derived from Coleus Forskohlii which directly stimulates adenylate cyclase (AC). This unique diterpene increases in levels of intracellular cyclic AMP (cAMP) from ATP in various eukaryotic cells by activating AC. cAMP is a second messenger mediating a variety of signaling pathways and is related to lipolysis via thermogenesis. It is reported that forskolin induces CYP3A gene expression in primary hepatocytes by functioning as agonists of the pregnane X receptor (PXR). Protein kinase A (PKA) signal transduction pathway activated by cAMP enhances CYP3A gene expression induced by PXR.

This compound is a potent inhibitor of platelet aggregation and proven for antitumor effects. cAMP signaling related to forskolin is relevant to the effects in induction of mesenchymal-to-epithelial transition, inhibition of cell proliferation and metastasis. In addition, it helps sensitivity to antitumor drugs enhanced in cancer cells.

The natural compound is also inotropic and has been used for hypertension and respiratory disorders as well.

 

Applications

• Study for signaling pathway

• Study for antitumor drug

• Inotropic agent 

 

Additional Reading

• AGS Blog: Forskolin for Weight Loss - A Natural Remedy!

 

References

• “Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?”

• “Forskolin: a unique diterpene activator of cyclic AMP-generating systems”

• “Forskolin: A potential antimetastatic agent”

• “The Natural cAMP Elevating Compound Forskolin in Cancer Therapy: Is It Time?”

• “Induction of Drug Metabolism by Forskolin: The Role of the Pregnane X Receptor and the Protein Kinase A Signal Transduction Pathway"

• “A New Potential Weapon for Fighting Obesity: Forskolin—the Active Diterpene in Coleus”

  

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Colforsin; Coleonol; colforsina; colforsine; colforsinum; Boforsin; Coleonolk
SKU
F-1026
CAS #
66575-29-9
Chemical Name
[(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate
Chemical Formula
C22H34O7
Molecular Weight
410.5 Da
Appearance
White crystalline solid
Purity
≥99%
Solubility
May be dissolved in DMSO (160 mg/mL) or Ethanol (50mg/mL)
Storage Temp
-20°C, desiccated, store up to 4 months.
THERAPEUTIC AREA
Cardiological Disorders
USE
Forskolin is commonly used as a tool in biochemistry to raise levels of cyclic AMP (cAMP) in the study and research of cell physiology. Forskolin activates the enzyme adenylyl cyclase and increases intracellular levels of cAMP. cAMP is an important second messenger necessary for the proper biological response of cells to hormones and other extracellular signals.
Merck Index
Merck Index: 13.2500.2001
MDL NUMBER
MFCD00082317
CHEMACX
X1009715-3
INCHI
InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
SMILES
CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O
Peptide sequence
Not Applicable
RTECS
QL6150000
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Avoid contact with skin, eyes, and personal clothing. Wash hands thoroughly after handling. Avoid breathing fumes. Use only with adequate ventilation. Wear suitable protective clothing, gloves, and eye/face protection. Keep away from sources of ignition. Minimize dust generation and accumulation. Keep container tightly closed. Open and handle container with care. Do not eat, drink, or smoke while handling.
msds 1
F-1026, Forskolin, SDS, diamond format, r01, 2020.pdf
Certificate of Analysis 1
F-1026, L1401.pdf
Certificate of Analysis 2
F-1026, K1585.pdf
Certificate of Analysis 3
F-1026, H1258C.pdf
GHS PICTOGRAMS
Handling Avoid contact with skin, eyes, and personal clothing. Wash hands thoroughly after handling. Avoid breathing fumes. Use only with adequate ventilation. Wear suitable protective clothing, gloves, and eye/face protection. Keep away from sources of ignition. Minimize dust generation and accumulation. Keep container tightly closed. Open and handle container with care. Do not eat, drink, or smoke while handling.
UN #'SNot Applicable
Packing GroupNot Applicable
CitationsHydrogen sulfide decreases β-adrenergic agonist-stimulated lung liquid clearance by inhibiting ENaC-mediated transepithelial sodium absorption
Stroma cell-derived factor-1α signaling enhances calcium transients and beating frequency in rat neonatal cardiomyocytes
Thyroid hydrogen peroxide production is enhanced by the Th2 cytokines, IL-4 and IL-13, through increased expression of the dual oxidase 2 and its maturation factor DUOXA2
Role of Epac and protein kinase A in thyrotropin-induced gene expression in primary thyrocytes
The Dual Oxidase Duox2 stabilized with DuoxA2 in an enzymatic complex at the surface of the cell produces extracellular H2O2 able to induce DNA damage in an inducible cellular model
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