Fostriecin is the most fully characterised member of a family of phosphate esters of a triene antibiotic. The antitumor potential of fostriecin has attracted considerable interest, focused on its mode of action as a topoisomerase II inhibitor. Subsequent research has focused on this metabolite's selective inhibition of protein phosphatase PP2A.
Phosphotrienin, CI 920, CL 1565A, PD 110161, NSC 339638
>95% by HPLC
Soluble in water (100 mM), and methanol
Fostriecin is an antibiotic