FSG67, GPAT inhibitor

SKU
F-2489
  • CAS:1158383-34-6
  • Formula:C16H25NO4S
  • MW:327.4 Da
  • Appearance:White solid
  • Purity:≥98% by TLC NMR (Conforms)
Product Name Qty
FSG67, GPAT inhibitor
50 mg
$212.95

Description and Applications

FSG67 is an inhibitor of Glycerol 3-Phosphate Acyltransferase (GPAT); IC50 = 24 μM. It was able to reduce food intake, decrease body weight and adiposity, enhance energy utilization as fatty acid oxidation, reverse hepatic steatosis, and enhance insulin sensitivity in diet-induced obese mice while showing no in vitro or in vivo toxicity.

FSG67 also caused decreased gene expression for orexigenic hypothalamic neuropeptides AgRP and NPY. FSG67 increased FAOx in primary hypothalamic neurons (PHN) leading to an increase in ATP and inactivation of AMPK. Oxidative stress and indicators of ER stress were also reduced in PHN.

More Information
Alternate Name/Synonyms
2-(Nonylsulfonamido)Benzoicacid; 2-(Nonylsulfonamido)benzoic Acid; 2-(nonylsulfonamido) benzoic acid
SKU
F-2489
CAS #
1158383-34-6
Chemical Name
2-(Nonylsulfonamido)benzoic acid
Chemical Formula
C16H25NO4S
Molecular Weight
327.4 Da
Appearance
White solid
Purity
≥98% by TLC NMR (Conforms)
Solubility
Soluble in DMSO (greater than 25 mg/mL) or in Ethanol (greater than 25 mg/mL)
Stability
Stable for 1 year as supplied. Solutions in DSMO or ethanol may be stored at -20° for up to 3 months
Storage Temp
-20°C
USE
Inhibitor of Glycerol 3-Phosphate Acyltransferase (GPAT)
Certificate of Analysis 1
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