FTI-277 Trifluoroacetate salt

SKU
F-1156
  • CAS:170006-73-2
  • Formula:C22H29N3O3S2•xC2HF3O2
  • MW:447.6
  • Appearance:Off-white, waxy Solid
  • Purity:95% by HPLC

2?

1

0

0

Product Name Qty
FTI-277 Trifluoroacetate salt
inquire
$0.00
Pro-drug form of FTI-276 that acts as a highly potent and selective inhibitor of FTase (IC = 50 nM). Inhibits H-Ras processing in whole cells (IC = 100 nM), but does not inhibit geranylgeranylated Rap1A processing.
More Information
SKU
F-1156
CAS #
170006-73-2
Chemical Formula
C22H29N3O3S2•xC2HF3O2
Molecular Weight
447.6
Appearance
Off-white, waxy Solid
Purity
95% by HPLC
Solubility
DMSO (100 mg/ml)
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells.
MDL NUMBER
MFCD00952925
CHEMACX
X1868206-9
INCHI
InChI=1S/C22H29N3O3S2/c1-28-22(27)20(10-11-30-2)25-21(26)18-9-8-17(24-13-16(23)14-29)12-19(18)15-6-4-3-5-7-15/h3-9,12,16,20,24,29H,10-11,13-14,23H2,1-2H3,(H,25,26)/t16-,20+/m1/s1
SMILES
COC(=O)[C@H](CCSC)NC(=O)c1ccc(cc1c2ccccc2)NC[C@H](CS)N
Handling
Hygroscopic. Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 week at -70°C.
Handling Hygroscopic. Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 week at -70°C.
To Top