FTY-720 Hydrochloride

SKU
F-1162
  • CAS:162359-56-0
  • Formula:C19H33NO2.HCl
  • MW:343.9
  • Appearance:Crystalline Solid
  • Purity:98%

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Product Name Qty
FTY-720 Hydrochloride
5 mg
$70.36
FTY-720 Hydrochloride
25 mg
$283.65

FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herbIscaria sinclari as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1p) receptors. Down-regulation of S1P receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer's patch. FTY720 also enhances the activity of the sphingosine transporter Abcb1 and the leukotriene C transporter Abcc1 and inhibits cystolic phospholipase A activity.

More Information
Alternate Name/Synonyms
Fingolimod
SKU
F-1162
CAS #
162359-56-0
Chemical Name
2-AMINO-2-(4-OCTYLPHENETHYL)PROPANE-1,3-DIOL HYDROCHLORIDE
Chemical Formula
C19H33NO2.HCl
Molecular Weight
343.9
Appearance
Crystalline Solid
Purity
98%
Solubility
Soluble in DMSO (10 mg / ml), 100% ethanol or Dimethyl formamide.
Stability
N/A
Melting Point
102-107 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Neurological Disorders
USE
FTY720 is an immunomodulating drug and sphingosine 1-phosphate (S1P) receptor modulator for treating multiple sclerosis
MDL NUMBER
MFCD00939512
CHEMACX
X1494471-1
PubChecm ID
N/A
INCHI
InChI=1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H
SMILES
CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N.Cl
RTECS
TY3130000
Handling
Stable for 1 year when stored at -20°C. Stock solutions stable 1-2 months when stored at -20°C.
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GHS PICTOGRAMS
Handling Stable for 1 year when stored at -20°C. Stock solutions stable 1-2 months when stored at -20°C.
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