FTY-720 Hydrochloride
- CAS:162359-56-0
- Formula:C19H33NO2.HCl
- MW:343.9
- Appearance:Crystalline Solid
- Purity:98%

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FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herbIscaria sinclari as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1p) receptors. Down-regulation of S1P receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer's patch. FTY720 also enhances the activity of the sphingosine transporter Abcb1 and the leukotriene C transporter Abcc1 and inhibits cystolic phospholipase A activity.
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Handling | Stable for 1 year when stored at -20°C. Stock solutions stable 1-2 months when stored at -20°C. |