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Fingolimod Hydrochloride, 50 MG

Price$ 89.00
  • SKU: F-1162-50MG
  • Pack Size: 50 MG
Quantity
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Fingolimod Hydrochloride, 50 MG

FTY720; 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol, hydrochloride

162359-56-0

343.9

C19H33NO2 • HCl

DMF, DMSO, Ethanol, Ethanol:PBS (pH 7.2)

-20°C


Fingolimod HCl is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herbIscaria sinclari as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1p) receptors. Down-regulation of S1P receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer's patch. FTY720 also enhances the activity of the sphingosine transporter Abcb1 and the leukotriene C transporter Abcc1 and inhibits cystolic phospholipase A activity.

 

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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