Fumagillin

SKU
F-1028
  • CAS:23110-15-8
  • Formula:C26H34O7
  • MW:458.6 Da
  • Appearance:Beige crystalline powder
  • Purity:≥99%

1

1

0

Product Name Qty
Fumagillin
10 mg
$173.13
Fumagillin
25 mg
$335.45
Fumagillin
1 mg
$50.86
Fumagillin
5 mg
$89.81

MetAP-2 inhibitor.Fumagillin is an inhibitor of endothelial cell proliferation and angiogenesis. Fumagillin is also being investigated as potential treatment of intestinal microsporidiosis.We investigated the role of fumagillin as a potential therapy in experimental Pulmonary Hypertension (PH). 1.Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents pulmonary hypertension in monocrotaline-injured rats.

More Information
Alternate Name/Synonyms
Amebacilin; Fugillin; Fumidil B; Fumidil
SKU
F-1028
CAS #
23110-15-8
Chemical Name
(2E,4E,6E,8E)-10-[[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid
Chemical Formula
C26H34O7
Molecular Weight
458.6 Da
Appearance
Beige crystalline powder
Purity
≥99%
Solubility
Dissolve in DMSO (25mg/ml) or Methanol (5mg/ml)
Melting Point
194-195 °C
Preparation
N/A
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
Infectious Diseases
USE
Fumagillin was originally used against microsporidian parasites Nosema apis infections in honey bees. Some studies found it to be effective against some myxozoan parasites, including Myxobolus cerebralis, an important parasite of fish; however, in the more rigorous tests required for U.S. Food and Drug Administration approval, it was ineffective.
Merck Index
N/A
MDL NUMBER
MFCD03990453
CHEMACX
X1009716-0
INCHI
InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20-,23-,24+,25+,26+/m1/s1
SMILES
CC(=CC[C@@H]1[C@@](O1)(C)[C@@H]2[C@@H]([C@@H](CC[C@]23CO3)OC(=O)/C=C/C=C/C=C/C=C/C(=O)O)OC)C
RTECS
HE1750000
Handling
Avoid contact with skin, eyes, and personal clothing. Wash hands thoroughly after handling. Avoid breathing fumes. Use only with adequate ventilation. Wear suitable protective clothing, gloves, and eye/face protection. Keep away from sources of ignition. Minimize dust generation and accumulation. Keep container tightly closed. Open and handle container with care. Do not eat, drink, or smoke while handling.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Avoid contact with skin, eyes, and personal clothing. Wash hands thoroughly after handling. Avoid breathing fumes. Use only with adequate ventilation. Wear suitable protective clothing, gloves, and eye/face protection. Keep away from sources of ignition. Minimize dust generation and accumulation. Keep container tightly closed. Open and handle container with care. Do not eat, drink, or smoke while handling.
To Top