Amebacilin; Fugillin; Fumidil B; Fumidil
23110-15-8
458.6
C26H34O7
DMSO, Methanol
-20°C
Fumagillin is used as an antimicrobial agent from Aspergillus fumigatus. It is a specific inhibitor of methionine aminopeptidase-2 (MetAP-2) by covalently binding histidine residue of it. It is reported that this fungal metabolite suppresses angiogenesis and proliferation of endothelial cells.
It is a potent treatment of intestinal microsporidiosis in immunocompromised patients. It is reported that a derivative of fumagillin, AGM-1470, is related to angioinhibitory action by suppressing of mRNA expression of specific members of CDKs and cyclins and activation of CDC2 and CDK2 kinases in endothelial cells.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
