Fumonisin B1

SKU
F-1022
  • CAS:116355-83-0
  • Formula:C34H59NO15‚·H2O
  • MW:721.8
  • Appearance:Beige powder
  • Purity:96.0% (TLC) and >99% (HLPC)

4

0

0

0

Product Name Qty
Fumonisin B1
1 mg
$117.25
Fumonisin B1
5 mg
$500.30

Fumonisins are a group of mycotoxins derived from species of the fungus Fusarium. Fumonisin B1 is a carcinogenic, toxic secondary metabolite that inhibits sphingomyelin biosynthesis in neuronal cells by impairing ceramide synthase. It is the most prevalent member of the fumonisin group and is isolated from Fusarium moniliforme (aka Fusarium verticilliodies). FB1 occurs mainly in corn, wheat and other cereals.

Fumonisin B1 is hepatoxic (causing liver damage) and nephrotoxic (causing kidney damage) to animals and is the known cause of diseases such as equine leukoencephalomalacia and porcine pulmonary oedema syndrome. The toxin causes disturbed sphingolipid metabolism and cardiovascular dysfunction in both diseases.

More Information
Alternate Name/Synonyms
Macrofusine, FB1
SKU
F-1022
CAS #
116355-83-0
Chemical Name
1,2,3-propanetricarboxylic acid 1,-1'-[1-(12-amino-4,9,11-trihydroxy-2-methyltridecyl)-2-(1-methylpentyl)-1,2-ethanediyl] ester
Chemical Formula
C34H59NO15‚·H2O
Molecular Weight
721.8
Appearance
Beige powder
Purity
96.0% (TLC) and >99% (HLPC)
Solubility
Soluble inDMSO (25mg/ml), methanol, 100% ethanol (25mg/ml), or acetone. Insoluble in water
Melting Point
N/A
Preparation
N/A
Storage Temp
+4°C
USE
Disruption of sphingolipid metabolism
Merck Index
N/A
RTECS
N/A
Citations
RESEARCH ARTICLES: A fluorescent sphingolipid binding domain peptide probe interacts with sphingolipids and cholesterol-dependent raft domains Sarita Hebbar, Esther Lee, Manoj Manna, Steffen Steinert, Goparaju Sravan Kumar, Markus Wenk, Thorsten Wohland, and Rachel Kraut J. Lipid Res., May 2008; 49: 1077 - 1089.
Citations_Hyperlink
http://www.jlr.org/cgi/reprint/49/5/1077
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
To Top