γ-Rubromycin

SKU
R-2473
  • Formula:C26H18O12
  • Appearance:Red powder
Product Name Qty
γ-Rubromycin
1 mg
$89.34
γ-Rubromycin
5 mg
$357.36

γ-Rubromycin isolated from Streptomyces sp. consists of a densely oxygenated naphthazarin ring and an isocoumarin moiety linked through a unique aromatic 5,6-sproketal ring system. The rubromycins exhibit a wide range of biological activity including antimicrobial and anticancer properties. 

β-Rubromycin and γ-rubromycin display potent activity against human telomerase(IC50=3µm), the reverse transcriptase of HIV-1, and the moloney murine leukemia virus. α-Rubromycin, the only member of the group to lack the aryl spiroketal moiety, exhibits substantially decreased inhibitory potency towards telomerase(IC50>200µm), which suggests that the spiroketal core is an essential pharmacophore for the inhibition of telomerase. Purpuromycin, a potential topical agent for vaginal infections, and heliquinomycin, a selective inhibitor of DNA helicase are structurally related to the rubromycins.

 

 

More Information
SKU
R-2473
Chemical Formula
C26H18O12
Appearance
Red powder
Solubility
Soluble in methylene chloride, DMSO or methanol
Storage Temp
-20°C
Hazard Image
Yes
Certificate of Analysis 1
/media/upload/pdf/R-2473, G1004.pdf
Promo text for AGS discount
N/A
GHS PICTOGRAMS
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