SDS
CofA
Cell-permeable. Acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC~ 5 M in SAG-stimulated Shh-L2 cells) and displays anti-proliferative and antitumor activity in vivo.
More Information
Alternate Name/Synonyms
2,3,4,5-Tetra(4-pyridyl)thiophene; NSC75503
SKU
G-2333
CAS #
64048-12-0
Chemical Name
2,3,4,5-Tetra(4-pyridyl)thiophene; NSC75503
Chemical Formula
C24H16N4S
Molecular Weight
392.48
Appearance
Yellow Solid
Purity
98% by HPLC
Solubility
DMSO (25 mM) or Ethanol (25 mM)
Melting Point
256-258 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells
MDL NUMBER
MFCD01103196
CHEMACX
X1197193-8
INCHI
InChI=1S/C24H16N4S/c1-9-25-10-2-17(1)21-22(18-3-11-26-12-4-18)24(20-7-15-28-16-8-20)29-23(21)19-5-13-27-14-6-19/h1-16H
SMILES
c1cnccc1c2c(c(sc2c3ccncc3)c4ccncc4)c5ccncc5
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from air and light
| Handling | Protect from air and light |
|---|---|
| UN #'S | Not Applicable |
| Packing Group | Not Applicable |
