GDC-0449

SKU
G-2334
  • CAS:879085-55-9
  • Formula:C19H14Cl2N2O3S
  • MW:421.3
  • Appearance:White to off-white Solid
  • Purity:98% by HPLC
Product Name Qty
GDC-0449
5 mg
$83.67
GDC-0449
25 mg
$269.21
GDC-0449, Vismodegib is a potent inhibitor of Smoothened (SMO), a key mediator of Hedgehog (Hh) signaling pathway. GDC-0449, Vismodegib inhibition of SMO renders the transcription factor GLI inactive, thus preventing the expression of genes that mediate the role of Hh on tumor growth.
More Information
Alternate Name/Synonyms
2-Chloro-N-(4-chloro-3-(pyridine-2-yl)phenyl)-4-(methylsulfonyl)benzamide; HhAntag691;Vismodegib
SKU
G-2334
CAS #
879085-55-9
Chemical Name
2-Chloro-N-(4-chloro-3-(pyridine-2-yl)phenyl)-4-(methylsulfonyl)benzamide; HhAntag691
Chemical Formula
C19H14Cl2N2O3S
Molecular Weight
421.3
Appearance
White to off-white Solid
Purity
98% by HPLC
Solubility
DMSO (200 mg/ml) or EtOH (10 mg/ml with warming)
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell
MDL NUMBER
MFCD12407408
CHEMACX
X1819852-0
INCHI
InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)
SMILES
CS(=O)(=O)c1ccc(c(c1)Cl)C(=O)Nc2ccc(c(c2)c3ccccn3)Cl
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from air and light
Promo text for AGS discount
N/A
GHS PICTOGRAMS
Handling Protect from air and light
UN #'S Not Applicable
Packing Group Not Applicable
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