GDC-0941

SKU
G-2335
  • CAS:957054-30-7
  • Formula:C23H27N7O3S2
  • MW:513.64
  • Appearance:Off-White Solid
  • Purity:99% by HPLC
Product Name Qty
GDC-0941
1 mg
$182.11
GDC-0941
5 mg
$623.62
GDC-0941 is a potent inhibitor of p110 and p110 (IC= 3 nM). It selectively binds to PI3K isoforms in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway.
More Information
Alternate Name/Synonyms
2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2- d]pyrimidine
SKU
G-2335
CAS #
957054-30-7
Chemical Name
2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2- d]pyrimidine
Chemical Formula
C23H27N7O3S2
Molecular Weight
513.64
Appearance
Off-White Solid
Purity
99% by HPLC
Solubility
DMSO
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
A potent inhibitor the PI 3-kinase family in tumor cell proliferation, induces apoptosis
MDL NUMBER
MFCD11616196
CHEMACX
X1759141-2
INCHI
InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27)
SMILES
CS(=O)(=O)N1CCN(CC1)Cc2cc3c(s2)c(nc(n3)c4cccc5c4cn[nH]5)N6CCOCC6
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from air and light
GHS PICTOGRAMS
Handling Protect from air and light
UN #'S Not Applicable
Packing Group Not Applicable
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