Gefitinib

SKU
C-1251
  • CAS:184475-35-2
  • Formula:C22H24ClFN4O3
  • MW:446.9
  • Appearance:A crystalline Solid
  • Purity:98%

Starting at $73.71

Product Name Qty
Gefitinib
1 g
$265.78
Gefitinib
5 g
$1,116.74
Gefitinib
250 mg
$73.71
Gefitinib
500 mg
$139.59
Over-activity of the epidermal growth factor receptor-associated tyrosine kinase (EGFR-TK) has been associated with a number of cancers and thus TK inhibitors could be potential therapeutic agents to prevent malignant growth. Gefitinib is a selective inhibitor of EGFR-TK inhibitor that blocks the growth of GEO colon cancer, ZR-75-1 and MCF-10A Ha-Ras breast cancer, and OVCAR-3 ovarian cancer cell lines with ICs ranging between 0.2-0.4M. By interfering with the intracellular kinase domain, gefitinib prevents EGFR auto-phosphorylation and prevents downstream signal transduction. Gefitinib has been used to treat advanced (or recurrent) non-small cell lung cancer. However, the FDA retracted its general approval for this compound (Iressa) when a phase III trial failed to demonstrate an overall survival benefit. Gefitinib appears to be most efficacious in treating certain EGFR gene mutations that are prevalent in Asian populations.
More Information
Alternate Name/Synonyms
Iressa, ZD1839
SKU
C-1251
CAS #
184475-35-2
Chemical Name
N-(3-chloro-4fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine
Chemical Formula
C22H24ClFN4O3
Molecular Weight
446.9
Appearance
A crystalline Solid
Purity
98%
Solubility
Soluble in ethanol (0.3 mg/ml), DMSO (20 mg/ml) or DMF (20 mg/ml), which should be purged of inert gas. Gefitinib is sparingly soluble in aqueous buffers.(For more information, please read Cof A).
Stability
N/A
Melting Point
193-194 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
An EGFR-tyrosine kinase inhibitor use in cancer
MDL NUMBER
MFCD04307832
CHEMACX
X1511922-9
INCHI
InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
SMILES
COc1cc2c(cc1OCCCN3CCOCC3)c(ncn2)Nc4ccc(c(c4)Cl)F
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
UN 3077
PACKING GROUP
III
HAZARD CLASS
Not Applicable
Handling
Room temperature
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
Promo text for AGS discount
N/A
GHS PICTOGRAMS
Handling Room temperature
UN #'S UN 3077
Packing Group III
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