Geninthiocin

SKU
G-2509
  • CAS:158792-27-9
  • Formula:C50H49N15O15S
  • MW:1132.1
  • Appearance:White Amorphous Powder
  • Purity:>95% by HPLC
Product Name Qty
Geninthiocin
0.5 mg
$361.32
Geninthiocin
2.5 mg
$1,123.49
*Please inquire the availability for this product. Geninthiocin, a thiopeptide antibiotic isolated from a Streptomyces sp., is a potent activator of the tipA gene, a bacterial transcription regulator involved in multidrug resistance. Geninthiocin displays a 10-fold selectivity for bacteria over mammalian cells lines, whereas the related dedialanyl geninthiocin shows the reverse selectivity. Geninthiocin is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.
More Information
Alternate Name/Synonyms
14-Demethylberinamycin
SKU
G-2509
CAS #
158792-27-9
Chemical Formula
C50H49N15O15S
Molecular Weight
1132.1
Appearance
White Amorphous Powder
Purity
>95% by HPLC
Solubility
Soluble in methanol, DMF, DMSO, and ethanol
Melting Point
270-275 °C
Storage Temp
4°C
THERAPEUTIC AREA
Infectious Diseases
USE
A thiopeptide antibiotic tipA gene activator
MDL NUMBER
MFCD09752730
INCHI
InChI=1S/C50H49N15O15S/c1-12-27-48-61-30(16-79-48)41(72)54-21(5)39(70)65-35(50(10,11)77)45(76)57-23(7)47-64-33(25(9)80-47)44(75)55-20(4)38(69)56-22(6)46-60-29(15-78-46)34-26(49-62-31(17-81-49)42(73)63-32(24(8)66)43(74)59-27)13-14-28(58-34)40(71)53-19(3)37(68)52-18(2)36(51)67/h12-17,24,32,35,66,77H,2-7H2,1,8-11H3,(H2,51,67)(H,52,68)(H,53,71)(H,54,72)(H,55,75)(H,56,69)(H,57,76)(H,59,74)(H,63,73)(H,65,70)/b27-12+
SMILES
C/C=C/1\c2nc(co2)C(=O)NC(=C)C(=O)NC(C(=O)NC(=C)c3nc(c(o3)C)C(=O)NC(=C)C(=O)NC(=C)c4nc(co4)-c5c(ccc(n5)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)-c6nc(cs6)C(=O)NC(C(=O)N1)C(C)O)C(C)(C)O
To Top