Geranylgeraniol

SKU
G-1013
  • CAS:24034-73-9
  • Formula:C20H34O
  • MW:290.5
  • Appearance:Colorless to light yellow oil / Pale yellow liquid
  • Purity:>90% (By GC)

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Product Name Qty
Geranylgeraniol
250 mg
$785.07

The diterpene Geranylgeraniol, a precursor to geranylgeranylpyrophosphate, is an intermediate in the mevalonate pathway. This compound has been shown to prevent bone re-absorption, inhibition of osteoclast formation, and kinase activation in vitro. It has a role in the regulation of several cellular processes and in the control of inflammatory response to enzymatic regulation and response to oxidative stress.

The capacity of the isoprenoid, geranylgeraniol, to reverse inflammatory conditions appears to be highly relevant. Geranylgeraniol has the ability to restore the physiological cellular homeostasis, influencing the main factors of the mitochondrial damage (such as the components of the Bcl-2 family members, Bax and Bak). Geranylgeraniol downregulates the level of HMG CoA reductase and suppresses the growth of human liver, lung, ovary, pancreas, colon, stomach, and blood tumors.

Geranylgeraniol has been documented to counteract the effects of fluvastatin by inhibiting activation of caspase-1 and production of IL-1. It has been found to induce apoptosis in HL-60 cells and also utilized for protein isoprenylation.

In cigarrette filter-based assays that measures certain chemicals to quantify the exposure to carcinogens and toxicants, geranylgeraniol is used as a surrogate Internal Standard (IS) or a positive control for the chemical Solanesol.

 

More Information
Alternate Name/Synonyms
3,7,11,15-Tetramethyl-2,6,10,14-hexadecatraen-1-ol, GG-OH, GGol, GGOH
SKU
G-1013
CAS #
24034-73-9
Chemical Name
3,7,11,15-Tetramethyl-2,6,10,14-hexadecatraen-1-ol
Chemical Formula
C20H34O
Molecular Weight
290.5
Appearance
Colorless to light yellow oil / Pale yellow liquid
Purity
>90% (By GC)
Storage Temp
-20°C Short term, -80°C recommended for long term.
THERAPEUTIC AREA
Not Available
USE
Geranylgeraniol is a diterpene alcohol which plays a role in several important biological processes
MDL NUMBER
MFCD00129083
CHEMACX
X1090846-4
INCHI
InChI=1S/C20H34O/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-21/h9,11,13,15,21H,6-8,10,12,14,16H2,1-5H3/b18-11+,19-13+,20-15+
SMILES
CC(=CCC/C(=C/CC/C(=C/CC/C(=C/CO)/C)/C)/C)C
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Store in Tightly Sealed Vial
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Store in Tightly Sealed Vial
UN #'S Not Applicable
Packing Group Not Applicable
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