Bisindolylmaleimide I (GF-109203X)

SKU

G-1063

CAS:133052-90-1
Formula:C₂₅H₂₄N₄O₂
MW:412.5
Appearance:Orange Solid
Purity:>98%

SDS

CofA

Product Name	Qty
Bisindolylmaleimide I (GF-109203X) 1 mg $108.21
Bisindolylmaleimide I (GF-109203X) 5 mg $305.28

Details

Cell-permeable kinase inhibitor with a selectivity for Protein Kinase C (PKC). For HCl form, inquire.

*Listed below are a few published articles demonstrating the use of our GF-109203X product. We respectfully thank them for their trust in our product. Inquire for a full reference list.

RECEPTORS AND SIGNAL TRANSDUCTION: Protein Phosphatase 2A mediates resensitization of the neurokinin 1 receptor. Murphy, J. E et al. Am J Physiol Cell Physiol. Oct 2011. 301: C780-C791.

Specifications

More Information

Alternate Name/Synonyms

Go 6850, GF-109203X, Bisindolylmaleimide I

SKU

G-1063

CAS #

133052-90-1

Chemical Name

2-[1-(3- Dimethylaminopropyl)-1H-indol-3-yl]-3-(1Hindol- 3-yl)-maleimide]

Chemical Formula

C₂₅H₂₄N₄O₂

Molecular Weight

412.5

Appearance

Orange Solid

Purity

>98%

Solubility

Soluble in DMSO.

Melting Point

208-210°C

Storage Temp

-20°C

Citations

RECEPTORS AND SIGNAL TRANSDUCTION: Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor Jane E. Murphy, Dirk Roosterman, Graeme S. Cottrell, Benjamin E. Padilla, Micha Feld, Eva Brand, Wendy J. Cedron, Nigel W. Bunnett, and Martin Steinhoff Am J Physiol Cell Physiol, Oct 2011; 301: C780 - C791.

Citations_Hyperlink

http://ajpcell.physiology.org/cgi/reprint/301/4/C780

Certificate of Analysis 1

G-1063, F1230A.pdf

Certificate of Analysis 2

G-1063, F1230.pdf

Certificate of Analysis 3

G-1063, E1258A.pdf

Reviews

Safety

GHS PICTOGRAMS

Citations

Citations	Lysophospholipids modulate voltage-gated calcium channel currents in pituitary cells; effects of lipid stress
	Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor
	Connective tissue growth factor/CCN2 stimulates actin disassembly through Akt/protein kinase B-mediated phosphorylation and cytoplasmic translocation of p27(Kip-1)
	Differential role of PKC isoforms in GnRH and phorbol 12-myristate 13-acetate activation of extracellular signal-regulated kinase and Jun N-terminal kinase
	A preformed signaling complex mediates GnRH-activated ERK phosphorylation of paxillin and FAK at focal adhesions in L beta T2 gonadotrope cells
	Direct stimulation of the transcellular and paracellular calcium transport in the rat cecum by prolactin
	1,25-dihydroxyvitamin D(3) rapidly stimulates the solvent drag-induced paracellular calcium transport in the duodenum of female rats
	Hypoxia regulates PGE(2) release and EP1 receptor expression in osteoblastic cells
	Parathyroid hormone (PTH) rapidly enhances CFTR-mediated HCO₃⁻ secretion in intestinal epithelium-like Caco-2 monolayer: a novel ion regulatory action of PTH
	Enhancement of calcium transport in Caco-2 monolayer through PKCzeta-dependent Cav1.3-mediated transcellular and rectifying paracellular pathways by prolactin
	Prolactin stimulates transepithelial calcium transport and modulates paracellular permselectivity in Caco-2 monolayer: mediation by PKC and ROCK pathways
	Involvement of protein kinase C and protein kinase A in the enhancement of L-type calcium current by GABAB receptor activation in neonatal hippocampus
	8-Cl-cAMP and its metabolite, 8-Cl-adenosine induce growth inhibition in mouse fibroblast DT cells through the same pathways: protein kinase C activation and cyclin B down-regulation
	Vasoactive intestinal peptide (VIP)-mediated expression and function of steroidogenic acute regulatory protein (StAR) in granulosa cells