Bisindolylmaleimide I (GF-109203X)

SKU
G-1063
  • CAS:133052-90-1
  • Formula:C25H24N4O2
  • MW:412.5
  • Appearance:Orange Solid
  • Purity:>98%

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Product Name Qty
Bisindolylmaleimide I (GF-109203X)
1 mg
$108.21
Bisindolylmaleimide I (GF-109203X)
5 mg
$305.28

Cell-permeable kinase inhibitor with a selectivity for Protein Kinase C (PKC). For HCl form, inquire.

*Listed below are a few published articles demonstrating the use of our GF-109203X  product. We respectfully thank them for their trust in our product. Inquire for a full reference list.

 

 
More Information
Alternate Name/Synonyms
Go 6850, GF-109203X, Bisindolylmaleimide I
SKU
G-1063
CAS #
133052-90-1
Chemical Name
2-[1-(3- Dimethylaminopropyl)-1H-indol-3-yl]-3-(1Hindol- 3-yl)-maleimide]
Chemical Formula
C25H24N4O2
Molecular Weight
412.5
Appearance
Orange Solid
Purity
>98%
Solubility
Soluble in DMSO.
Melting Point
208-210°C
Storage Temp
-20°C
Citations
RECEPTORS AND SIGNAL TRANSDUCTION: Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor Jane E. Murphy, Dirk Roosterman, Graeme S. Cottrell, Benjamin E. Padilla, Micha Feld, Eva Brand, Wendy J. Cedron, Nigel W. Bunnett, and Martin Steinhoff Am J Physiol Cell Physiol, Oct 2011; 301: C780 - C791.
Citations_Hyperlink
http://ajpcell.physiology.org/cgi/reprint/301/4/C780
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Citations Lysophospholipids modulate voltage-gated calcium channel currents in pituitary cells; effects of lipid stress
Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor
Connective tissue growth factor/CCN2 stimulates actin disassembly through Akt/protein kinase B-mediated phosphorylation and cytoplasmic translocation of p27(Kip-1)
Differential role of PKC isoforms in GnRH and phorbol 12-myristate 13-acetate activation of extracellular signal-regulated kinase and Jun N-terminal kinase
A preformed signaling complex mediates GnRH-activated ERK phosphorylation of paxillin and FAK at focal adhesions in L beta T2 gonadotrope cells
Direct stimulation of the transcellular and paracellular calcium transport in the rat cecum by prolactin
1,25-dihydroxyvitamin D(3) rapidly stimulates the solvent drag-induced paracellular calcium transport in the duodenum of female rats
Hypoxia regulates PGE(2) release and EP1 receptor expression in osteoblastic cells
Parathyroid hormone (PTH) rapidly enhances CFTR-mediated HCO₃⁻ secretion in intestinal epithelium-like Caco-2 monolayer: a novel ion regulatory action of PTH
Enhancement of calcium transport in Caco-2 monolayer through PKCzeta-dependent Cav1.3-mediated transcellular and rectifying paracellular pathways by prolactin
Prolactin stimulates transepithelial calcium transport and modulates paracellular permselectivity in Caco-2 monolayer: mediation by PKC and ROCK pathways
Involvement of protein kinase C and protein kinase A in the enhancement of L-type calcium current by GABAB receptor activation in neonatal hippocampus
8-Cl-cAMP and its metabolite, 8-Cl-adenosine induce growth inhibition in mouse fibroblast DT cells through the same pathways: protein kinase C activation and cyclin B down-regulation
Vasoactive intestinal peptide (VIP)-mediated expression and function of steroidogenic acute regulatory protein (StAR) in granulosa cells
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