Gliotoxin

SKU
G-2521
  • CAS:67-99-2
  • Formula:C13H14N2O4S2
  • MW:326
  • Appearance:White powder
  • Purity:>99% by HPLC
Product Name Qty
Gliotoxin
1 mg
$113.02
Gliotoxin
5 mg
$396.19

*Please inquire the availability for this product. Gliotoxin is a potent epithiodioxopiperazine mycotoxin produced by species of Gliocladium, Aspergillus and Penicillium. At the cellular level gliotoxin inhibits a broad range of unrelated mechanisms, including inhibition of chymotrypsin-like activity of the 20S proteasome and Ca2+ release from mitochondria, activation of transcription factor NF-αºB in response to a variety of stimuli in T and B cells, anti-inflammatory activity, and inhibition of farnesyltransferase and geranylgeranyltransferase. The mode of action appears to be via covalent interaction with proteins through mixed disulphide formation. Gliotoxin inhibits a number of thiol-requiring enzymes and also displays antioxidant and immunomodulatory activity.

More Information
Alternate Name/Synonyms
Aspergillin, SN 12879, SN 12870
SKU
G-2521
CAS #
67-99-2
Chemical Formula
C13H14N2O4S2
Molecular Weight
326
Appearance
White powder
Purity
>99% by HPLC
Solubility
Soluble in DMSO (10 mg/ml), methanol (10 mg/ml), chloroform (10 mg/ml), DMF, and Pyridine
Storage Temp
4°C
USE
A toxic epipolythiodioxopiperazine metabolite that induces apoptosis and inhibits NF-kB
MDL NUMBER
MFCD00058534
INCHI
InChI=1S/C13H14N2O4S2/c1-14-10(18)12-5-7-3-2-4-8(17)9(7)15(12)11(19)13(14,6-16)21-20-12/h2-4,8-9,16-17H,5-6H2,1H3/t8-,9-,12+,13+/m0/s1
SMILES
CN1C(=O)[C@]23CC4=CC=C[C@@H]([C@H]4N2C(=O)[C@]1(SS3)CO)O
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