Glyburide [Glibenclamide]

SKU
G-1185
  • CAS:10238-21-8
  • Formula:C23H28ClN3O5S
  • MW:494.0
  • Appearance:White to off-white solid
  • Purity:≥99% (HPLC)
Product Name Qty
Glyburide [Glibenclamide]
500 mg
$119.99
Glyburide [Glibenclamide]
1 g
$174.99

Description

Glyburide (also known as Glibenclamide) is an anti-diabetic agent. It acts as an ATP-dependent K+ channel blocker in the pancreas, which in turn causes intracellular Ca2+ levels to rise and for insulin to be secreted.

Glyburide blocks vascular smooth muscle relaxation produced by KATP channel openers.

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Glibenclamide; Glybenclamide; Glynase; 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide; N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N′-cyclohexylurea
SKU
G-1185
CAS #
10238-21-8
Chemical Name
5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
Chemical Formula
C23H28ClN3O5S
Molecular Weight
494.0
Appearance
White to off-white solid
Purity
≥99% (HPLC)
Solubility
DMSO (100 mM) or EtOH (5 mM)
Storage Temp
2-8°C
THERAPEUTIC AREA
Diabetes
USE
Anti-diabetic agent. ATP-dependent K+ channel blocker.
MDL NUMBER
MFCD00056625
PubChecm ID
3488
INCHI
InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)
SMILES
COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3
Handling
Protect from air and moisture.
Certificate of Analysis 1
Certificate of Analysis 2
GHS PICTOGRAMS
HandlingProtect from air and moisture.
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