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Gö 6976

SKU
G-1017
  • CAS:136194-77-9
  • Formula:C24H18N4O
  • MW:378.4
  • Appearance:Off-White to Yellow Solid
  • Purity:≥99%

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CofA
Product Name Qty
Go 6976
500 ug
$241.47
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Cell-permeable. A potent protein kinase C (PKC) inhibitor (IC₅₀ = 7.9 nM). In vitro, discriminates between Ca²⁺- dependent and -independent isoforms of PKC; selectively inhibits PKCα and PKCβ1 (IC₅₀ values are 2.3 and 6.2 nM respectively) but does not inhibit the activity of PKCδ, -ε, or -ζ (IC₅₀>3μM).

Attached is a published references from researchers who have used our Gö 6976 product. We respectfully thank them for their trust in our product. Inquire for a full reference list.

http://mcb.asm.org/content/24/19/8374.full.pdf+html

 



More Information
Alternate Name/Synonyms
Go6976; PD 406976
SKU
G-1017
CAS #
136194-77-9
Chemical Name
5,6,7,13-Tetrahydro-13-methyl-5-oxo-12Hindolo[ 2,3-a]py-rrolo[3,4-c]carbazole-12- propanenitrile
Chemical Formula
C24H18N4O
Molecular Weight
378.4
Appearance
Off-White to Yellow Solid
Purity
≥99%
Solubility
H2O (10 mg/ml)
Storage Temp
-20°C
Certificate of Analysis 1
G-1017_G-1017,_B1161.pdf
Certificate of Analysis 2
G-1017_G-1017,_B1720.pdf
Citations Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5
Promiscuous actions of small molecule inhibitors of the protein kinase D-class IIa HDAC axis in striated muscle
Desensitization of somatostatin-induced inhibition of low extracellular magnesium concentration-induced calcium spikes in cultured rat hippocampal neurons
Growth-stimulatory activity of TIMP-2 is mediated through c-Src activation followed by activation of FAK, PI3-kinase/AKT, and ERK1/2 independent of MMP inhibition in lung adenocarcinoma cells
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