GSK-1120212

SKU
G-2339
  • CAS:871700-17-3
  • Formula:C26H23FIN5O4
  • MW:615.39
  • Appearance:Off-White Solid
  • Purity:98% by HPLC
Product Name Qty
GSK-1120212
1 mg
$85.43
GSK-1120212
5 mg
$336.03
A potent and selective allosteric inhibitor of the MEK1 (IC= 0.7 nM) and MEK2 (IC= 0.9 nM) enzymes with potential antineoplastic activity.
More Information
Alternate Name/Synonyms
N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide; JTP-74057
SKU
G-2339
CAS #
871700-17-3
Chemical Name
N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide; JTP-74057
Chemical Formula
C26H23FIN5O4
Molecular Weight
615.39
Appearance
Off-White Solid
Purity
98% by HPLC
Solubility
DMSO (~ 10 mg/ml)
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
A potent and selective allosteric inhibitor of the MEK1 and MEK2 enzymes with potential antineoplastic activity
MDL NUMBER
MFCD17215075
CHEMACX
X3162736-6
INCHI
InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)
SMILES
CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from light and air
Handling Protect from light and air
UN #'S Not Applicable
Packing Group Not Applicable
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