GSK-126

SKU
G-2379
  • CAS:1346574-57-9
  • Formula:C31H38N6O2
  • MW:526.67
  • Appearance:Tan powder
  • Purity:≥99%
Product Name Qty
GSK-126
25 mg
$275.00
GSK-126
1 mg
$49.50
GSK-126
5 mg
$93.50

GSK-126 is an inhibitor of mutant EZH2, a histone methyltransferase (HMT) that exhibits point mutations at key residues Tyr641 and Ala677; this compound does not appreciably affect WT EZH2. EZH2 is responsible for modulating expression of a variety of genes. GSK-126 competes with cofactor S-adenylmethionine (SAM) for binding to EZH2. GSK-126 displays anticancer chemotherapeutic activity by inhibiting proliferation in in vitro and in vivo models of diffuse large B-cell lymphoma.

More Information
SKU
G-2379
CAS #
1346574-57-9
Chemical Name
1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-methyl-6-(6-piperazin-1-ylpyridin-3-yl)indole-4-carboxamide
Chemical Formula
C31H38N6O2
Molecular Weight
526.67
Appearance
Tan powder
Purity
≥99%
Solubility
Soluble in DMSO
Storage Temp
-20°C
Hazard Image
Yes
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