GSK-2126458

SKU
G-2340
  • CAS:1086062-66-9
  • Formula:C25H17F2N5O3S
  • MW:505.5
  • Appearance:Off-white solid
  • Purity:≥98% by HPLC
Product Name Qty
GSK-2126458
1 mg
$108.21
GSK-2126458
5 mg
$427.15

Cell-permeable. A highly potent, pan phosphoinositide 3-kinase (PI 3-K) family kinase inhibitor with biochemical Ki’s of 0.019 nM (PI 3-K⍺), 0.13 nM (PI 3-Kβ), 0.024 nM (PI 3-Kδ), 0.06 nM (PI 3-Kɣ), 0.18 nM (mTORC1), and 0.3 nM (mTORC2). In vivo, GSK2126458 displays anti-tumor activity in both pharmacodynamic and tumor growth efficacy models.

More Information
SKU
G-2340
CAS #
1086062-66-9
Chemical Name
2,4-Difluoro-N-{2-(methyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide
Chemical Formula
C25H17F2N5O3S
Molecular Weight
505.5
Appearance
Off-white solid
Purity
≥98% by HPLC
Solubility
DMSO (~ 5 mg/ml)
Storage Temp
-20°C
GHS PICTOGRAMS
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